ArticleJournal of neurophysiology2022
Oropharyngeal capsaicin exposure improves infant feeding performance in an animal model of superior laryngeal nerve damage.
Article in Journal of neurophysiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 16 citations in OpenAlex.
- Association Between Salivary Substance P and Aspiration on Videofluoroscopic Swallow Study in Infants and Toddlers.The Journal of pediatrics · 2026Article
- A ducted, biomimetic nipple replicates breastfeeding mechanics through ontogeny in an infant animal model.Pediatric research · 2026Article
- Marmoset (Callithrix jacchus) Swallowing Physiology: Novel Dysphagia Model Across Lifespan.Integrative and comparative biology · 2026Article
- Mechanisms of Improving Feeding Function With Capsaicin Following Local Anesthesia in Infant Pigs.The Laryngoscope · 2025Article
- A Machine Learning Pipeline for Automated Bolus Segmentation and Area Measurement in Swallowing Videofluoroscopy Images of an Infant Pig Model.Dysphagia · 2025Article
- Infant pigs demonstrate motor adaptation across multiple physiologic functions during feeding in response to dynamic changes in milk flow rate.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Article
- A Ducted, Biomimetic Nipple Improves Aspects of Infant Feeding Physiology and Performance in an Animal Model.Dysphagia · 2025Article
- Age-Related Changes in Marmoset (Callithrix jacchus) Feeding Behavior and Physiology: Insights of Masticatory and Swallowing Functions.American journal of primatology · 2025Article
- The Sensory Gatekeeper of the Larynx: Anatomy and Clinical Importance of the Internal Branch of the Superior Laryngeal Nerve.Diagnostics (Basel, Switzerland) · 2025Review
- Muscle function and electromyography: (almost) 70 years since Doty and Bosma (1956).Journal of neurophysiology · 2025Article
- The effects of simulated gastroesophageal reflux on infant pig oropharyngeal feeding physiology.American journal of physiology. Gastrointestinal and liver physiology · 2024Article
- The Impact of Varying Nipple Properties on Infant Feeding Physiology and Performance Throughout Ontogeny in a Validated Animal Model.Dysphagia · 2024Article
- Transient receptor potential channels as an emerging therapeutic target for oropharyngeal dysphagia.The Japanese dental science review · 2023Review
- Exploring the interaction of viscosity and nipple design on feeding performance in an infant pig model.Journal of texture studies · 2023Article
- Nipple properties affect sensorimotor integration during bottle feeding in an infant pig model.Journal of experimental zoology. Part A, Ecological and integrative physiology · 2023Article
- The Function of the Mammal Extrinsic Tongue Musculature in the Transition from Suckling to Drinking.Integrative and comparative biology · 2023Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Sensorimotor feedback is critical to safe and effective swallowing. Because of this, sensory interventions have the potential to treat dysphagia. One such treatment may be found in capsaicin, which activates the internal branch of the superior laryngeal nerve (iSLN). The iSLN initiates the pharyngeal swallow, and a more sensitive iSLN should more readily elicit swallowing and improve swallow safety. We explored the neurophysiological mechanism by which capsaicin improves swallow performance using an infant pig model with a unilateral iSLN lesion. Using high-speed videofluoroscopy, we collected oropharyngeal kinematic data while pigs suckled on bottles, before and after applying capsaicin to the posterior tongue and valleculae. We found that capsaicin application decreased maximal bolus sizes, which improved swallow safety. Furthermore, capsaicin improved performance when infant pigs swallowed more moderately sized boluses. However, capsaicin did not change swallow frequency, the number of sucks prior to each swallow, nor total pharyngeal transit time (TPT). Similarly, excursions of the hyoid, thyroid, and posterior tongue were unchanged. TPT and hyoid and thyroid excursions maintained relationships with bolus size post-capsaicin, suggesting that these variables are less sensitive to sensory intervention. The timing and extent of posterior tongue movement were only correlated with bolus size pre-capsaicin, which could imply that capsaicin fundamentally changes in relationships between tongue movements and bolus size. Our results provide insight into the neural control of swallowing and capsaicin's mechanism of action, and suggest that capsaicin may be beneficial in treating acute infant dysphagia.
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