ArticleHuman brain mapping2022
Superficial white matter microstructure affects processing speed in cerebral small vessel disease.
Article in Human brain mapping, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Research progress on the application of functional magnetic resonance imaging in cognitive dysfunction in patients with cerebral small vessel disease.Frontiers in neurology · 2025Pooled it
- Exploring cerebral small vessel disease signatures in familial Parkinson's disease.Scientific reports · 2026Article
- A high-resolution functional network-organized atlas of human superficial white matter from ultra-high-field diffusion MRI.iScience · 2026Article
- Altered structural connectivity in white matter lesion-induced mild cognitive impairment: a probabilistic fiber tracking and graph theory analysis.Frontiers in neural circuits · 2026Article
- Data-driven subtypes of mild cognitive impairment and their modifiable determinants: latent profile analysis of the BIOCIS cohort.NPJ dementia · 2026Article
- Impaired capillary-venous drainage contributes to gliosis and demyelination in mouse white matter during aging.Nature neuroscience · 2025Article
- Glymphopathy and Reduced Processing Speed in Community-Dwelling Adults with Silent Cerebral Small Vessel Disease: A DTI-ALPS Study.Journal of clinical medicine · 2025Article
- Microstructural Characterization of Short Association Fibers Related to Long-Range White Matter Tracts in Normative Development.Human brain mapping · 2025Article
- The Shape of the Brain's Connections Is Predictive of Cognitive Performance: An Explainable Machine Learning Study.Human brain mapping · 2025Review
- Clinical and Pathophysiologic Correlates of Basilar Artery Measurements in Fabry Disease.AJNR. American journal of neuroradiology · 2024Article
- Surface-Based Probabilistic Fiber Tracking in Superficial White Matter.IEEE transactions on medical imaging · 2024Article
- U-fiber analysis: a toolbox for automated quantification of U-fibers and white matter hyperintensities.Quantitative imaging in medicine and surgery · 2024Article
- Imaging of the superficial white matter in health and disease.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Cerebral Amyloid Angiopathy: An Undeniable Small Vessel Disease.Journal of stroke · 2024Review
- Dynamic functional network connectivity in patients with a mismatch between white matter hyperintensity and cognitive function.Frontiers in aging neuroscience · 2024Article
- Superficial white matter microstructure affects processing speed in cerebral small vessel disease.Human brain mapping · 2022Article
- Association of systemic inflammatory markers with white matter hyperintensities and microstructural injury: an analysis of UK Biobank data.Journal of psychiatry & neuroscience : JPNArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 2 institutions in 2 countries.
Funding
Abstract
White matter hyperintensities (WMH) are a typical feature of cerebral small vessel disease (CSVD), which contributes to about 50% of dementias worldwide. Microstructural alterations in deep white matter (DWM) have been widely examined in CSVD. However, little is known about abnormalities in superficial white matter (SWM) and their relevance for processing speed, the main cognitive deficit in CSVD. In 141 CSVD patients, processing speed was assessed using Trail Making Test Part A. White matter abnormalities were assessed by WMH burden (volume on T2-FLAIR) and diffusion MRI measures. SWM imaging measures had a large contribution to processing speed, despite a relatively low SWM WMH burden. Across all imaging measures, SWM free water (FW) had the strongest association with processing speed, followed by SWM mean diffusivity (MD). SWM FW was the only marker to significantly increase between two subgroups with the lowest WMH burdens. When comparing two subgroups with the highest WMH burdens, the involvement of WMH in the SWM was accompanied by significant differences in processing speed and white matter microstructure. Mediation analysis revealed that SWM FW fully mediated the association between WMH volume and processing speed, while no mediation effect of MD or DWM FW was observed. Overall, results suggest that the SWM has an important contribution to processing speed, while SWM FW is a sensitive imaging marker associated with cognition in CSVD. This study extends the current understanding of CSVD-related dysfunction and suggests that the SWM, as an understudied region, can be a potential target for monitoring pathophysiological processes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.