ReviewChemical Society reviews2022
C-H bond activation and sequential addition to two different coupling partners: a versatile approach to molecular complexity.
Review in Chemical Society reviews, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Diastereoselective synthesis of substituted cyclopentanonesChemical science · 2026Article
- Visible Light Promoted Alkenyl C-H Bond Addition to Dienes and Aldehydes for the Synthesis of Frameworks Relevant to Polyketide Natural Products.ACS catalysis · 2026Article
- C-H Activation and Sequential Addition to Dienes and Imines: Synthesis of Amines withACS catalysis · 2024Article
- Synthesis of α-Quaternary Amides via Cp*Co(III)-Catalyzed Sequential C-H Bond Addition to 1,3-Dienes and Isocyanates.Organic letters · 2024Article
- Article
- Trialkoxysilane-Induced Iridium-Catalyzed para-Selective C-H Bond Borylation of Arenes.Nature communications · 2024Article
- Exploration of 2D and 3D-QSAR analysis and docking studies for novel dihydropteridone derivatives as promising therapeutic agents targeting glioblastoma.Frontiers in pharmacology · 2023Article
- Three-component carboformylation: α-quaternary aldehyde synthesisChemical science · 2022Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Sequential multicomponent C-H bond addition is a powerful approach for the rapid, modular generation of molecular complexity in a single reaction. In this approach, C-H bonds are typically added across π-bonds or π-bond isosteres, followed by subsequent coupling to another type of functionality, thereby forming two σ-bonds in a single reaction sequence. Many sequential C-H bond addition reactions have been developed to date, including additions across both conjugated and isolated π-systems followed by coupling with reactants such as carbonyl compounds, cyanating reagents, aminating reagents, halogenating reagents, oxygenating reagents, and alkylating reagents. These atom-economical reactions transform ubiquitous C-H bonds under mild conditions to more complex structures with a high level of regiochemical and stereochemical control. Surprising connectivities and diverse mechanisms have been elucidated in the development of these reactions. Given the large number of possible combinations of coupling partners, there are enormous opportunities for the discovery of new sequential C-H bond addition reactions.
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Registered trials
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