Evidence map›Paper›PMID 35822273›Full record

ArticleInfluenza and other respiratory viruses2022

Epidemiological analysis of the first 1000 cases of SARS-CoV-2 lineage BA.1 (B.1.1.529, Omicron) compared with co-circulating Delta in Wales, UK.

Nicole Pacchiarini, Clare Sawyer, Christopher Williams, Daryn Sutton, Christopher Roberts, Felicity Simkin, Grace King, Victoria McClure, Simon Cottrell, Helen Clayton and 5 more

Abstract read
In one paragraph

Article in Influenza and other respiratory viruses, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
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  5. Review
  6. Article
  7. Article
  8. Interaction of Laurusides 1 and 2 with the 3C-like Protease (MInternational journal of molecular sciences · 2023
    Article
  9. Article
  10. Article
  11. Article
  12. Observational
  13. Article
  14. SARS-CoV-2 Omicron BA.5: Riding the seventh wave in Central Canada.Influenza and other respiratory viruses · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Nicole PacchiariniCommunicable Disease Surveillance Centre (CDSC), Public Health Wales, Cardiff, Wales, UK.ORCID 0000-0001-5383-6053
Clare SawyerCommunicable Disease Surveillance Centre (CDSC), Public Health Wales, Cardiff, Wales, UK.ORCID 0000-0003-2679-7217
Christopher WilliamsCommunicable Disease Surveillance Centre (CDSC), Public Health Wales, Cardiff, Wales, UK.ORCID 0000-0002-5092-4987
Daryn SuttonCommunicable Disease Surveillance Centre (CDSC), Public Health Wales, Cardiff, Wales, UK.
Christopher RobertsCommunicable Disease Surveillance Centre (CDSC), Public Health Wales, Cardiff, Wales, UK.
Felicity SimkinCommunicable Disease Surveillance Centre (CDSC), Public Health Wales, Cardiff, Wales, UK.
Grace KingCommunicable Disease Surveillance Centre (CDSC), Public Health Wales, Cardiff, Wales, UK.
Victoria McClureCommunicable Disease Surveillance Centre (CDSC), Public Health Wales, Cardiff, Wales, UK.
Simon CottrellCommunicable Disease Surveillance Centre (CDSC), Public Health Wales, Cardiff, Wales, UK.ORCID 0000-0003-0645-2764
Helen ClaytonInformatics Division, Operations and Finance Directorate, Public Health Wales, Cardiff, Wales, UK.
Andrew BeazerPathogen Genomics Unit, Public Health Wales, Cardiff, Wales, UK.
Catie WilliamsPathogen Genomics Unit, Public Health Wales, Cardiff, Wales, UK.ORCID 0000-0003-3654-3923
Sara M ReyPathogen Genomics Unit, Public Health Wales, Cardiff, Wales, UK.ORCID 0000-0002-6196-022X
Thomas R ConnorPathogen Genomics Unit, Public Health Wales, Cardiff, Wales, UK.ORCID 0000-0003-2394-6504
Catherine MooreWales Specialist Virology Centre, Microbiology, Public Health Wales, Cardiff, Wales, UK.ORCID 0000-0001-8934-0930

Funding

Medical Research Council MR/L015080Medical Research Council MR/T030062/1Medical Research Council MR/V028367/1
6 · The paper itself

Abstract

backgroundThe Omicron (lineage B.1.1.529) variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first reported in Wales, UK, on 3 December 2021. The aim of the study was to describe the first 1000 cases of the Omicron variant by demographic, vaccination status, travel and severe outcome status and compare this to contemporaneous cases of the Delta variant.

methodsTesting, typing and contact tracing data were collected by Public Health Wales and analysis undertaken by the Communicable Disease Surveillance Centre (CDSC). Risk ratios for demographic factors and symptoms were calculated comparing Omicron cases to Delta cases identified over the same time period.

resultsBy 14 December 2021, 1000 cases of the Omicron variant had been identified in Wales. Of the first 1000, just 3% of cases had a prior history of travel revealing rapid community transmission. A higher proportion of Omicron cases were identified in individuals aged 20-39, and most cases were double vaccinated (65.9%) or boosted (15.7%). Age-adjusted analysis also revealed that Omicron cases were less likely to be hospitalised (0.4%) or report symptoms (60.8%). Specifically a significant reduction was observed in the proportion of Omicron cases reporting anosmia (8.9%).

conclusionKey findings include a lower risk of anosmia and a reduced risk of hospitalisation in the first 1000 Omicron cases compared with co-circulating Delta cases. We also identify that existing measures for travel restrictions to control importations of new variants identified outside the United Kingdom did not prevent the rapid ingress of Omicron within Wales.

Indexed as

COVID-19SARS-CoV-2AnosmiaHumansUnited KingdomWalesCOVID-19GenomicsOmicronSARS-CoV-2SurveillanceWales

Identifiers

PMID35822273
PMCPMC9350272

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.