Evidence map›Paper›PMID 35822179›Full record

ArticleAdvanced functional materials2021

FAP-Targeted Photodynamic Therapy Mediated by Ferritin Nanoparticles Elicits an Immune Response against Cancer Cells and Cancer Associated Fibroblasts.

Shiyi Zhou, Zipeng Zhen, Amy V Paschall, Lijun Xue, Xueyuan Yang, Anne-Gaelle Bebin-Blackwell, Zhengwei Cao, Weizhong Zhang, Mengzhe Wang, Yong Teng and 5 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced functional materials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 1 pooled it
3.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 1 synthesis or guideline pooled it, 86 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Review
  11. Review
  12. Article
  13. Review
  14. Review
  15. Review
  16. Article
  17. Review
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 2 countries.

Shiyi ZhouDepartment of Chemistry, University of Georgia, Athens, GA 30602, USA.
Zipeng ZhenDepartment of Chemistry, University of Georgia, Athens, GA 30602, USA.
Amy V PaschallDepartment of Biochemistry and Molecular Biology, Center for Molecular Medicine and Complex Carbohydrate Research Center, University of Georgia, Athens, GA 30602, USA.
Lijun XueDepartment of Medical Oncology, Jinling Hospital, Nanjing University Clinical School of Medicine, Nanjing, Jiangsu 210002, China.
Xueyuan YangDepartment of Chemistry, University of Georgia, Athens, GA 30602, USA.
Anne-Gaelle Bebin-BlackwellCenter for Vaccines and Immunology, University of Georgia, Athens, GA 30605, USA.
Zhengwei CaoDepartment of Chemistry, University of Georgia, Athens, GA 30602, USA.
Weizhong ZhangDepartment of Chemistry, University of Georgia, Athens, GA 30602, USA.
Mengzhe WangDepartment of Radiology, Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Yong TengGeorgia Cancer Center, Augusta University, Augusta, GA 30912, USA.
Gang ZhouGeorgia Cancer Center, Augusta University, Augusta, GA 30912, USA.
Zibo LiDepartment of Radiology, Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Fikri Y AvciDepartment of Biochemistry and Molecular Biology, Center for Molecular Medicine and Complex Carbohydrate Research Center, University of Georgia, Athens, GA 30602, USA.
Wei TangDepartment of Chemistry, University of Georgia, Athens, GA 30602, USA.
Jin XieDepartment of Chemistry, University of Georgia, Athens, GA 30602, USA.
University of Georgia · USAugusta University Health · USUniversity of North Carolina at Chapel Hill · USNanjing General Hospital of Nanjing Military Command · CN

Funding

Implementing a Maternal health and PRegnancy Outcomes Vision for Everyone (IMPROVE)UL1TR002378 · NCATS · EMORY UNIVERSITY · PI Andres J Garcia, Elizabeth O. Ofili · 2017 to 2026
$92.1M
Nanoscintillator-based X-ray sensitizers to enable efficient NSCLC treatment with X-ray irradiationR01EB022596 · NIBIB · UNIVERSITY OF GEORGIA · PI XIE, JIN · 2017 to 2020
$1.9M
NCATS NIH HHS UL1 TR002378NIBIB NIH HHS R01 EB022596
6 · The paper itself

Abstract

Cancer-associated fibroblasts (CAFs) are present in many types of tumors and play a pivotal role in tumor progression and immunosuppression. Fibroblast-activation protein (FAP), which is overexpressed on CAFs, has been indicated as a universal tumor target. However, FAP expression is not restricted to tumors, and systemic treatment against FAP often causes severe side effects. To solve this problem, a photodynamic therapy (PDT) approach was developed based on ZnF

Indexed as

cancer associated fibroblastfibroblast activation proteinimmunomodulationimmunotherapyphotodynamic therapy

Identifiers

PMID35822179
PMCPMC9273013
OpenAlexW3100976542

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.