Evidence map›Paper›PMID 35821997›Full record

ArticleFrontiers in aging2021

Removal of

Steve D Guzman, Jennifer Judge, Shahjahan M Shigdar, Thomas A Paul, Carol S Davis, Peter C Macpherson, James F Markworth, Holly Van Remmen, Arlan Richardson, Anne McArdle and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. The impact of cellular senescence on aging skeletal muscle.Frontiers in cell and developmental biology · 2025
    Review
  4. Sesamol Alleviates Sarcopenia via Activating AKT/mTOR/FoxO1 Signal Pathway in Aged Obese Mice.Plant foods for human nutrition (Dordrecht, Netherlands) · 2024
    Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Steve D GuzmanDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, United States.
Jennifer JudgeDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, United States.
Shahjahan M ShigdarDepartment of Musculoskeletal Biology, Institute of Ageing and Chronic Disease, University of Liverpool and MRC-Arthritis Research UK Centre for Integrated Research Into Musculoskeletal Ageing (CIMA), Liverpool, United Kingdom.
Thomas A PaulDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, United States.
Carol S DavisDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, United States.
Peter C MacphersonDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, United States.
James F MarkworthDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, United States.
Holly Van RemmenAging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, United States.
Arlan RichardsonOklahoma City VA Medical Center, Oklahoma City, OK, United States.
Anne McArdleDepartment of Musculoskeletal Biology, Institute of Ageing and Chronic Disease, University of Liverpool and MRC-Arthritis Research UK Centre for Integrated Research Into Musculoskeletal Ageing (CIMA), Liverpool, United Kingdom.
Susan V BrooksDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, United States.
University of Michigan–Ann Arbor · USUniversity of Liverpool · GBOklahoma City VA Medical Center · USUniversity of Oklahoma Health Sciences Center · US

Funding

PROJECT 3: Neuromuscular redox homeostasis in mice lacking SOD1 and aging wild type mice subcontract at University of LiverpoolP01AG051442 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI JACKSON, MALCOLM JOSEPH · 2016 to 2020
$8.9M
Michigan IRACDA: Training Future Professors of Engineering and PhysiologyK12GM111725 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BROOKS, SUSAN V, SEPT, DAVID · 2016 to 2025
$7.9M
BLRD VA IK6 BX005238Medical Research Council MR/P020941/1NIA NIH HHS P01 AG051442NIGMS NIH HHS K12 GM111725
6 · The paper itself

Abstract

Aging results in the progressive accumulation of senescent cells in tissues that display loss of proliferative capacity and acquire a senescence-associated secretory phenotype (SASP). The tumor suppressor, p16

Indexed as

aginginflammationmuscle atrophysarcopeniasenescence

Identifiers

PMID35821997
PMCPMC9261355
OpenAlexW4210745772

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.