Evidence map›Paper›PMID 35821909›Full record

ReviewSN applied sciences2022

Secondary plant metabolites as potent drug candidates against antimicrobial-resistant pathogens.

Kadiatou Keita, Charles Darkoh, Florence Okafor

Open access · goldAbstract readReview
In one paragraph

Review in SN applied sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
10.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 77 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Chemical Profiling andNutrients · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Bioactivity-Guided Isolation of Flavone Glycoside fromMolecules (Basel, Switzerland) · 2025
    Article
  13. Review
  14. Review
  15. Article
  16. Review
  17. Article
  18. Antibacterial Activity of Metabolites of EndophyticInternational journal of microbiology · 2025
    Article
  19. Antibacterial Potential ofInternational journal of microbiology · 2025
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Kadiatou KeitaBiological & Environmental Sciences, Alabama Agricultural & Mechanical University, Normal, AL 35762 USA.
Charles DarkohDepartment of Epidemiology, School of Public Health, Center for Infectious Diseases, Human Genetics, and Environmental Sciences, University of Texas Health Science Center, Houston, TX 77030 USA.ORCID 0000-0003-0063-7856
Florence OkaforBiological & Environmental Sciences, Alabama Agricultural & Mechanical University, Normal, AL 35762 USA.
Alabama Agricultural and Mechanical University · USThe University of Texas MD Anderson Cancer Center · US

Funding

Characterizing Vancomycin-Resistant C. difficile Strains at Two Geographically Distinct LocationsR01AI150685 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI DARKOH, CHARLES · 2021 to 2025
$3.4M
Targeting the Toxins: A Novel Non-Antimicrobial Approach to Combat Clostridium difficile infectionsR01AI116914 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI DARKOH, CHARLES · 2015 to 2019
$1.9M
NIAID NIH HHS L30 AI126518NIAID NIH HHS R01 AI116914NIAID NIH HHS R01 AI150685
6 · The paper itself

Abstract

Antibiotic resistance is a major public health threat of the twenty-first century and represents an important risk to the global economy. Healthcare-associated infections mainly caused by drug-resistant bacteria are wreaking havoc in patient care worldwide. The spread of such pathogens limits the utility of available drugs and complicates the treatment of bacterial diseases. As a result, there is an urgent need for new drugs with mechanisms of action capable of curbing resistance. Plants synthesize and utilize various metabolic compounds to deter pathogens and predators. Utilizing these plant-based metabolites is a promising option in identifying novel bioactive compounds that could be harnessed to develop new potent antimicrobial drugs to treat multidrug-resistant pathogens. The purpose of this review is to highlight medicinal plants as important sources of novel antimicrobial agents that could be developed to help combat antimicrobial resistance.

Indexed as

Antibacterial drug screeningAnti-infective agentsAntimicrobial resistanceMultidrug-resistant pathogensPlant-based medical compoundsPlant metabolitesPlant secondary metabolites

Identifiers

PMID35821909
PMCPMC9264742
OpenAlexW4284969959

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.