Evidence map›Paper›PMID 35821884›Full record

ArticleGreen chemistry letters and reviews2021

Metal-free domino amination-Knoevenagel condensation approach to access new coumarins as potent nanomolar inhibitors of VEGFR-2 and EGFR.

Essam M Eliwa, Marcel Frese, Ahmed H Halawa, Maha M Soltan, Larissa V Ponomareva, Jon S Thorson, Khaled A Shaaban, Mohamed Shaaban, Ahmed M El-Agrody, Norbert Sewald

Abstract read
In one paragraph

Article in Green chemistry letters and reviews, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Coumarin-furo[2,3-RSC medicinal chemistry · 2024
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Essam M EliwaOrganic and Bioorganic Chemistry, Faculty of Chemistry, Bielefeld University, Bielefeld, Germany.ORCID 0000-0001-5570-1427
Marcel FreseOrganic and Bioorganic Chemistry, Faculty of Chemistry, Bielefeld University, Bielefeld, Germany.
Ahmed H HalawaChemistry Department, Faculty of Science, Al-Azhar University, Nasr City-Cairo, Egypt.
Maha M SoltanBiology Unit, Central Laboratory for Pharmaceutical and Drug Industries Research Division, Chemistry of Medicinal Plants Department, Pharmaceutical and Drug Industries Research Division, National Research Centre Cairo, Egypt.ORCID 0000-0002-7370-0142
Larissa V PonomarevaCenter for Pharmaceutical Research and Innovation, University of Kentucky, Lexington, USA.ORCID 0000-0003-2182-8774
Jon S ThorsonCenter for Pharmaceutical Research and Innovation, University of Kentucky, Lexington, USA.ORCID 0000-0002-7148-0721
Khaled A ShaabanCenter for Pharmaceutical Research and Innovation, University of Kentucky, Lexington, USA.ORCID 0000-0001-7638-4942
Mohamed ShaabanOrganic and Bioorganic Chemistry, Faculty of Chemistry, Bielefeld University, Bielefeld, Germany.ORCID 0000-0001-9281-2505
Ahmed M El-AgrodyChemistry Department, Faculty of Science, Al-Azhar University, Nasr City-Cairo, Egypt.ORCID 0000-0001-7019-411X
Norbert SewaldOrganic and Bioorganic Chemistry, Faculty of Chemistry, Bielefeld University, Bielefeld, Germany.ORCID 0000-0002-0309-2655

Funding

Kentucky Center for Clinical and Translational ScienceUL1TR001998 · NCATS · UNIVERSITY OF KENTUCKY · PI HARTMANN, KATHERINE E, KERN, PHILIP A · 2016 to 2025
$34.2M
Understanding the role of anti-apolipoprotein A-I antibodies in atherosclerotic cardiovascular diseaseP20GM130456 · NIGMS · UNIVERSITY OF KENTUCKY · PI M. Ashfaqul Alam · 2020 to 2026
$18.7M
Kentucky Center for Clinical and Translational ScienceUL1TR000117 · NCATS · UNIVERSITY OF KENTUCKY · PI KERN, PHILIP A · 2012 to 2015
$13.3M
Platform technologies for understanding and exploiting methylationR01GM115261 · NIGMS · UNIVERSITY OF KENTUCKY · PI PHILLIPS, GEORGE NEAL, THORSON, JON SCOTT · 2016 to 2019
$2.2M
NCATS NIH HHS UL1 TR000117NCATS NIH HHS UL1 TR001998NIGMS NIH HHS P20 GM130456NIGMS NIH HHS R01 GM115261
6 · The paper itself

Abstract

A metal-free, atom-economy and simple work-up domino amination-Knoevenagel condensation approach to construct new coumarin analogous (

Indexed as

C–N couplingCoumarinEGFRKnoevenagel condensationmetal-free domino reactionVEGFR-2

Identifiers

PMID35821884
PMCPMC9273165

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.