ArticleClinical neuropsychiatry2022
Circadian Rhythm Alterations May be Related to Impaired Resilience, Emotional Dysregulation and to the Severity of Mood Features in Bipolar I and II Disorders.
Article in Clinical neuropsychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Resilience in Bipolar Disorder Compared to Clinical and Non-Clinical Populations: A Systematic Review and Meta-Analysis.Acta psychiatrica Scandinavica · 2026Pooled it
- Allostatic and Circadian Drives in Patients with Bipolar Disorder in Depressive Episodes or with Post-Traumatic Stress Disorder Versus Healthy Controls: Neuroendocrine Comparison Through Cortisol and 6-Sulfatoxymelatonin Overnight Urine Excretion.International journal of molecular sciences · 2026Article
- Autism spectrum traits in adults with attention-deficit/hyperactivity disorder (ADHD): a hidden multifaceted phenotype marked by affective comorbidity, emotional dysregulation, and chronobiological disturbances.European archives of psychiatry and clinical neuroscience · 2026Article
- The Theory of Metabolic Jet Lag in Bipolar Disorder: A Pilot Feasibility Study Exploring the Association Between Eating Rhythm Disruption and Illness Burden Parameters.Bipolar disorders · 2026Article
- Irregularity in Daily Activities Predicts Depression via Reduced Perceived Control: A Daily Diary Study.Journal of clinical psychology · 2026Article
- Emotion regulation and depressive symptoms mediate the association between chronotype and suicidality.Acta neuropsychiatrica · 2026Article
- Relationship between emotion regulation skills, resilience, depression and anxiety symptom severity in patients with mood disorders and non-clinical participants: a mediation model.European archives of psychiatry and clinical neuroscience · 2026Article
- Association between biological rhythm disruption and suicidal ideation in patients with major depressive disorder: a chain mediation of neuroticism and emotion regulation difficulties.Frontiers in psychiatry · 2026Article
- A large-scale study of chronic sleep disorders in psychiatric inpatients: Prevalence, hospitalization burden, restraint use, and comorbidities.European psychiatry : the journal of the Association of European Psychiatrists · 2025Article
- Circadian rhythm parameters differentiate euthymic, manic and depressive mood states in bipolar disorders - an explorative pilot study.International journal of bipolar disorders · 2025Article
- Twenty-Four Hour Rest-Activity Rhythm Disturbances and Neural Alterations Associated With Emotion Regulation in Shift Workers.Journal of sleep research · 2025Article
- The Types of Psychosocial Factors Associated with Suicidality Outcomes for People Living with Bipolar Disorder: A Scoping Review.International journal of environmental research and public health · 2024Article
- The Role of Emotion Dysregulation in Understanding Suicide Risk: A Systematic Review of the Literature.Healthcare (Basel, Switzerland) · 2024Review
- AnFrontiers in molecular biosciences · 2024Article
- Resilience and Attachment in Patients with Major Depressive Disorder and Bipolar Disorder.Journal of personalized medicine · 2023Article
- The stress of losing sleep: Sex-specific neurobiological outcomes.Neurobiology of stress · 2023Article
- Review
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: The study aimed to investigate the possible impact of resilience and emotion dysregulation on the clinical manifestations of bipolar disorders (BDs) focusing on the possible role of circadian rhythm alterations. Method: A sample of 197 inpatients suffering from BD of type I (BDI) or II (BDII) were assessed during a major depressive episode using the Structural Clinical Interview for DSM-5 (SCID-5), the Beck Depression Inventory-II (BDI-II), the Young Mania Rating Scale (YMRS), Resilience Scale for Adults (RSA), Biological Rhythms Interview of Assessment in Neuropsychiatry (BRIAN), Difficulties in Emotion Regulation Scale (DERS) and the Scale for Suicide Ideation (SSI). Participants with or without circadian rhythm disturbances as measured with Biological Rhythms Interview of Assessment in Neuropsychiatry (BRIAN), were compared; regression and mediation analyses were computed. Results: Participants with circadian rhythms disturbances showed a greater severity of depressive symptoms, of suicidal risk, lower resilience and more disturbances in emotion regulation including impulsivity and regulatory strategies. The logistic regression revealed that circadian rhythm disturbances was related to depressive symptoms (O.R. 4.0), suicidal risk (OR 2.51), emotion dysregulation (OR 2.28) and low resilience (OR 2.72). At the mediation analyses, circadian rhythm alterations showed an indirect effect on depressive symptoms by impairing resilience (Z= 3.17, p=0.0014)/ emotional regulation (Z= 4.36, p<0.001) and on suicidal risk by affecting resilience (Z= 2.00, p=0.045) and favoring impulsivity (Z= 2.14, p=0.032). Conclusions: The present findings may show that circadian rhythm alterations might play a key role in BD manifestations, as being correlated with more severe clinical presentations of depressive symptoms, suicidal risk, impaired resilience and emotional regulation. Addressing circadian rhythm alterations might potentially promote resilience and emotion regulation hence improving mood symptoms and suicidal risk in BDs.
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