Evidence map›Paper›PMID 35821813›Full record

ArticleFrontiers in aging2022

Low But Recoverable Markers of Humoral Immune Response to BNT162b2 in Elderly LTCF Residents Five to Seven Months After Two-Dose Vaccination.

Marla Delbrück, Sebastian Hoehl, Tuna Toptan, Barbara Schenk, Katharina Grikscheit, Melinda Metzler, Eva Herrmann, Sandra Ciesek

Open access · goldAbstract read
In one paragraph

Article in Frontiers in aging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
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  3. Pediatric cancer patients vaccinated against SARS-CoV-2-a clinical and laboratory follow-up.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Marla DelbrückInstitute of Medical Virology, Goethe University Frankfurt, Frankfurt, Germany.
Sebastian HoehlInstitute of Medical Virology, Goethe University Frankfurt, Frankfurt, Germany.
Tuna ToptanInstitute of Medical Virology, Goethe University Frankfurt, Frankfurt, Germany.
Barbara SchenkInstitute of Medical Virology, Goethe University Frankfurt, Frankfurt, Germany.
Katharina GrikscheitInstitute of Medical Virology, Goethe University Frankfurt, Frankfurt, Germany.
Melinda MetzlerInstitute of Medical Virology, Goethe University Frankfurt, Frankfurt, Germany.
Eva HerrmannInstitute of Biostatistics and Mathematical Modeling, Goethe University Frankfurt, Frankfurt, Germany.
Sandra CiesekInstitute of Medical Virology, Goethe University Frankfurt, Frankfurt, Germany.
Goethe University Frankfurt · DEGerman Center for Infection Research · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The immune response is known to wane after vaccination with BNT162b2, but the role of age, morbidity and body composition is not well understood. We conducted a cross-sectional study in long-term care facilities (LTCFs) for the elderly. All study participants had completed two-dose vaccination with BNT162b2 five to 7 months before sample collection. In 298 residents (median age 86 years, range 75-101), anti-SARS-CoV-2 rector binding IgG antibody (anti-RBD-IgG) concentrations were low and inversely correlated with age (mean 51.60 BAU/ml). We compared the results to Health Care Workers (HCW) aged 18-70 years (

Indexed as

COVID-19elderlyimmunityimmunosenescencemultimorbiditySARS-CoV-2vaccination

Identifiers

PMID35821813
PMCPMC9261435
OpenAlexW4224324181

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.