Evidence map›Paper›PMID 35821801›Full record

ArticleFrontiers in aging2022

Geranylgeranylacetone Ameliorates Beta-Amyloid Toxicity and Extends Lifespan

Isiah Mossiah, Sabrina M Perez, Taylor R Stanley, Michaela K Foley, Karen S Kim Guisbert, Eric Guisbert

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in aging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Isiah MossiahDepartment of Biomedical and Chemical Engineering and Sciences, Florida Institute of Technology, Melbourne, FL, United States.
Sabrina M PerezDepartment of Biomedical and Chemical Engineering and Sciences, Florida Institute of Technology, Melbourne, FL, United States.
Taylor R StanleyDepartment of Biomedical and Chemical Engineering and Sciences, Florida Institute of Technology, Melbourne, FL, United States.
Michaela K FoleyDepartment of Biomedical and Chemical Engineering and Sciences, Florida Institute of Technology, Melbourne, FL, United States.
Karen S Kim GuisbertDepartment of Biomedical and Chemical Engineering and Sciences, Florida Institute of Technology, Melbourne, FL, United States.
Eric GuisbertDepartment of Biomedical and Chemical Engineering and Sciences, Florida Institute of Technology, Melbourne, FL, United States.
Florida Institute of Technology · US

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
Regulatory mechanisms linking HSF1 protein levels and HSF1 protein activity to the alternative splicing factor SF3B1R15CA227573 · NCI · FLORIDA INSTITUTE OF TECHNOLOGY · PI GUISBERT, ERIC · 2019 to 2019
$430k
NCI NIH HHS R15 CA227573NIH HHS P40 OD010440
6 · The paper itself

Abstract

Activation of a cytoprotective cellular pathway known as the heat shock response (HSR) is a promising strategy for the treatment of Alzheimer's disease and other neurodegenerative diseases. Geranylgeranylacetone (GGA) is a commonly used anti-ulcer drug in Japan that has been shown to activate the HSR. Here, we establish

Indexed as

agingAlzheimer’s diseasedrug repurposinggeranylgeranylacetoneheat shock responseHSF1lifespanlongevity

Identifiers

PMID35821801
PMCPMC9261441
OpenAlexW4285413461

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.