Evidence map›Paper›PMID 35821501›Full record

ArticleScientific reports2022

Intrauterine growth restriction and its impact on intestinal morphophysiology throughout postnatal development in pigs.

Thaís Garcia Santos, Saffir Dominique Fernandes, Stefany Bruna de Oliveira Araújo, Fernando Felicioni, Thaís de Mérici Domingues E Paula, André Lucas Caldeira-Brant, Soraia Viana Ferreira, Luciana de Paula Naves, Stefânia Priscilla de Souza, Paulo Henrique Reis Furtado Campos and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
9.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 26 citations in OpenAlex.

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  17. Gut Health and Influencing Factors in Pigs.Animals : an open access journal from MDPI · 2023
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  19. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Thaís Garcia SantosLaboratory of Structural Biology and Reproduction, Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Antônio Carlos Avenue, 6627, Belo Horizonte, MG, 31270-901, Brazil.
Saffir Dominique FernandesLaboratory of Structural Biology and Reproduction, Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Antônio Carlos Avenue, 6627, Belo Horizonte, MG, 31270-901, Brazil.
Stefany Bruna de Oliveira AraújoLaboratory of Structural Biology and Reproduction, Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Antônio Carlos Avenue, 6627, Belo Horizonte, MG, 31270-901, Brazil.
Fernando FelicioniLaboratory of Structural Biology and Reproduction, Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Antônio Carlos Avenue, 6627, Belo Horizonte, MG, 31270-901, Brazil.
Thaís de Mérici Domingues E PaulaLaboratory of Structural Biology and Reproduction, Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Antônio Carlos Avenue, 6627, Belo Horizonte, MG, 31270-901, Brazil.
André Lucas Caldeira-BrantLaboratory of Structural Biology and Reproduction, Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Antônio Carlos Avenue, 6627, Belo Horizonte, MG, 31270-901, Brazil.
Soraia Viana FerreiraLaboratory of Structural Biology and Reproduction, Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Antônio Carlos Avenue, 6627, Belo Horizonte, MG, 31270-901, Brazil.
Luciana de Paula NavesDepartment of Animal Science, Federal University of Lavras, University Campus, PO Box 3037, Lavras, MG, 37200-000, Brazil.
Stefânia Priscilla de SouzaDepartment of Animal Science, Federal University of Lavras, University Campus, PO Box 3037, Lavras, MG, 37200-000, Brazil.
Paulo Henrique Reis Furtado CamposDepartment of Animal Science, Federal University of Viçosa, Viçosa, MG, 36570-900, Brazil.
Hélio Chiarini-GarciaLaboratory of Structural Biology and Reproduction, Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Antônio Carlos Avenue, 6627, Belo Horizonte, MG, 31270-901, Brazil.
Ana Luísa Neves Alvarenga DiasFederal University of Uberlândia, BR 050 Km 78, Uberlândia, MG, 38410-337, Brazil.
Fernanda Radicchi Campos Lobato de AlmeidaLaboratory of Structural Biology and Reproduction, Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Antônio Carlos Avenue, 6627, Belo Horizonte, MG, 31270-901, Brazil. falmeida@icb.ufmg.br.
Universidade Federal de Minas Gerais · BRUniversidade Federal de Lavras · BRUniversidade Federal de Uberlândia · BRUniversidade Federal de Viçosa · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intrauterine growth restriction (IUGR) compromises fetal development, leading to low birth weight, and predisposes to gastrointestinal disorders. Pigs that suffered IUGR present poor postnatal development, resulting in great economic losses to the industry. The small intestine may be involved with impaired development, but studies investigating this issue are still limited. Thus, the present study aimed to investigate small intestine morphofunctional alterations in IUGR pigs throughout the production phases (birth to 150 days). IUGR pigs presented lower body weight from birth to the finishing phase (P < 0.05). Although histomorphometrical parameters were not affected during the pre-weaning period, their commitment was observed specifically in the duodenum of the IUGR group at older ages (P < 0.05). The most detrimental effects on the small intestine, such as deeper duodenum crypts' depth, lower villus height:crypt depth ratio and absorptive area, increased apoptosis and lower proliferation of the duodenum epithelium were noticed at 70 days of age (P < 0.05). Additionally, IUGR pigs presented the lowest chymotrypsin and amylase activities at 70 and 150 days of age, respectively (P < 0.05). These findings may contribute to the elucidation of morphofunctional disorders of the small intestine in IUGR pigs throughout the different production phases, suggesting that poor postnatal development may be due to intestinal damage.

Indexed as

Fetal Growth RetardationIntestinesAnimalsFemaleHumansIntestinal MucosaParturitionPregnancySwineWeaning

Identifiers

PMID35821501
PMCPMC9276813
OpenAlexW4285091542

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.