Evidence map›Paper›PMID 35821452›Full record

ArticleJournal of clinical immunology2022

Post-SARS-CoV-2 Atypical Inflammatory Syndrome in a Toddler with X-Linked Inhibitor of Apoptosis Deficiency After Stem Cell Transplant.

Prasanth G Narahari, Jennifer Gebbia, Warren Alperstein, Gary Kleiner, Melissa Gans

Open access · bronzeAbstract readLetter
PubMed Publisher
In one paragraph

Article in Journal of clinical immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Severity of SARS-CoV-2 infection in children with inborn errors of immunity (primary immunodeficiencies): a systematic review.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2023
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Prasanth G NarahariDepartment of Pediatrics, Holtz Children's Hospital at Jackson Memorial Hospital, University of Miami Miller School of Medicine, 1580 NW 10th Ave, Miami, FL, 33136, USA. pgnarahari@yahoo.com.
Jennifer GebbiaDivision of Allergy and Immunology, Department of Pediatrics, Holtz Children's Hospital at Jackson Memorial Hospital, University of Miami Miller School of Medicine, 1580 NW 10th Ave, Miami, FL, 33136, USA.
Warren AlpersteinDivision of Pediatric Hematology, Oncology, and Bone Marrow Transplant, Department of Pediatrics, Holtz Children's Hospital at Jackson Memorial Hospital, University of Miami Miller School of Medicine, 1475 NW 12th Avenue, Miami, FL, 33136, USA.
Gary KleinerDivision of Pediatric Allergy and Immunology, Department of Pediatrics, Holtz Children's Hospital at Jackson Memorial Hospital, University of Miami Miller School of Medicine, 1580 NW 10th Ave, Miami, FL, 33136, USA.
Melissa GansDivision of Pediatric Allergy and Immunology, Department of Pediatrics, Holtz Children's Hospital at Jackson Memorial Hospital, University of Miami Miller School of Medicine, 1580 NW 10th Ave, Miami, FL, 33136, USA.
Jackson Memorial Hospital · USUniversity of Miami · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 10-month-old boy was diagnosed with X-linked lymphoproliferative syndrome type 2 due to X-linked inhibitor of apoptosis deficiency after presenting with failure to thrive and refractory inflammatory bowel disease. He underwent a matched unrelated donor stem cell transplant with reduced intensity conditioning at 16 months. At 27 months, he presented with an atypical inflammatory syndrome in the setting of recent COVID-19 infection, Epstein-Barr viremia, and low chimerism (7.3%). He recovered after treatment with intravenous immunoglobulin and steroids.

Indexed as

COVID-19Hematopoietic Stem Cell TransplantationLymphoproliferative DisordersApoptosisChild, PreschoolGenetic Diseases, X-LinkedHumansInfantMaleSARS-CoV-2X-Linked Inhibitor of Apoptosis ProteinX-Linked Inhibitor of Apoptosis ProteinAtypical inflammatory syndromebone marrow transplantCOVID-19multisystem inflammatory syndrome in children (MIS-C)primary immunodeficiencySARS-CoV-2stem cell transplantX-linked inhibitor of apoptosis deficiency (XIAP)X-linked lymphoproliferative (XLP)

Identifiers

PMID35821452
OpenAlexW4285094777

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.