ArticleCommunications biology2022
Suppression without inhibition: how retinal computation contributes to saccadic suppression.
Article in Communications biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 14 citations in OpenAlex.
- Microsaccadic eye movement generation is sufficient to enhance peripheral visual sensitivity.PLoS biology · 2026Article
- Comparing masking and habituation roles in saccadic omission of stimuli optimized for intra-saccadic vision.Journal of vision · 2026Article
- Much higher covariation with foveation timing by superior colliculus than primary visual cortical neuronal activity.iScience · 2026Article
- Preemptive gain control in primary visual cortex.Current biology : CB · 2025Article
- Diverse and dynamic influences of saccades on visual representations in the mouse superior colliculus.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Stronger premicrosaccadic sensitivity enhancement for dark contrasts in the primate superior colliculus.Scientific reports · 2025Article
- Microsaccadic suppression of peripheral perceptual detection performance as a function of foveated visual image appearance.Journal of vision · 2024Article
- Visual Feature Tuning Properties of Short-Latency Stimulus-Driven Ocular Position Drift Responses during Gaze Fixation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Suppression without inhibition: how retinal computation contributes to saccadic suppression.Communications biology · 2022Article
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Authors and funding
9 authors at 6 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Visual perception remains stable across saccadic eye movements, despite the concurrent strongly disruptive visual flow. This stability is partially associated with a reduction in visual sensitivity, known as saccadic suppression, which already starts in the retina with reduced ganglion cell sensitivity. However, the retinal circuit mechanisms giving rise to such suppression remain unknown. Here, we describe these mechanisms using electrophysiology in mouse, pig, and macaque retina, 2-photon calcium imaging, computational modeling, and human psychophysics. We find that sequential stimuli, like those that naturally occur during saccades, trigger three independent suppressive mechanisms in the retina. The main mechanism is triggered by contrast-reversing sequential stimuli and originates within the receptive field center of ganglion cells. It does not involve inhibition or other known suppressive mechanisms like saturation or adaptation. Instead, it relies on temporal filtering of the inherently slow response of cone photoreceptors coupled with downstream nonlinearities. Two further mechanisms of suppression are present predominantly in ON ganglion cells and originate in the receptive field surround, highlighting another disparity between ON and OFF ganglion cells. The mechanisms uncovered here likely play a role in shaping the retinal output following eye movements and other natural viewing conditions where sequential stimulation is ubiquitous.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.