Evidence map›Paper›PMID 35821256›Full record

ArticleGene therapy2023

Loss of RAGE prevents chronic intermittent hypoxia-induced nonalcoholic fatty liver disease via blockade of NF-кB pathway.

Haoqu Tan, Jinfang Hu, Wei Zuo, Yun Huang, Jian Cui, Fei Gong, Wei Bai

Abstract read
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In one paragraph

Article in Gene therapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Nutrients · 2024
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Haoqu TanJiangxi Institute of Translational Medicine, The First Affiliated Hospital of Nanchang University, Nanchang, 330006, P. R. China.
Jinfang HuDepartment of Pharmacy, The First Affiliated Hospital of Nanchang University, Nanchang, 330006, P. R. China.
Wei ZuoDepartment of Respiration, The First Affiliated Hospital of Nanchang University, Nanchang, 330006, P. R. China.
Yun HuangDepartment of Otolaryngology Head and Neck Surgery, Ganzhou People's Hospital, Ganzhou, 341000, P. R. China.
Jian CuiDepartment of Respiration, The First Affiliated Hospital of Nanchang University, Nanchang, 330006, P. R. China.
Fei GongDepartment of Respiration, The First Affiliated Hospital of Nanchang University, Nanchang, 330006, P. R. China.
Wei BaiJiangxi Institute of Translational Medicine, The First Affiliated Hospital of Nanchang University, Nanchang, 330006, P. R. China. ndyfy03435@ncu.edu.cn.ORCID 0000-0001-7451-2672
Nanchang University · CNGanzhou People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In recent years, receptor for advanced glycation end-products (RAGE) has been documented to induce liver fibrosis and inflammatory reaction. Further, microarray data analysis of this study predicted high expression of RAGE in non-alcoholic fatty liver disease (NAFLD). However, its specific mechanisms remain to be elucidated. Hence, this study is aimed at investigating the mechanistic insights of RAGE in chronic intermittent hypoxia (CIH)-induced NAFLD. ApoE knockout (ApoE

Indexed as

Non-alcoholic Fatty Liver DiseaseAnimalsApolipoproteins EHypoxiaInflammationLiverMiceNF-kappa BReceptor for Advanced Glycation End ProductsApolipoproteins ENF-kappa BReceptor for Advanced Glycation End Products

Identifiers

PMID35821256
OpenAlexW4285090512

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.