Evidence map›Paper›PMID 35821124›Full record

ArticleNature communications2022

Genomic epidemiology of Delta SARS-CoV-2 during transition from elimination to suppression in Aotearoa New Zealand.

Lauren Jelley, Jordan Douglas, Xiaoyun Ren, David Winter, Andrea McNeill, Sue Huang, Nigel French, David Welch, James Hadfield, Joep de Ligt and 1 more

Abstract read
In one paragraph

Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

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  17. Heterogeneity of the COVID-19 epidemic: what can we learn from it?American journal of translational research · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Lauren Jelley *Institute of Environmental Science and Research, Wellington, New Zealand.
Jordan Douglas *Centre for Computational Evolution, School of Computer Science, University of Auckland, Auckland, New Zealand.ORCID 0000-0003-0371-9961
Xiaoyun RenInstitute of Environmental Science and Research, Wellington, New Zealand.
David WinterInstitute of Environmental Science and Research, Wellington, New Zealand.
Andrea McNeillInstitute of Environmental Science and Research, Wellington, New Zealand.
Sue HuangInstitute of Environmental Science and Research, Wellington, New Zealand.ORCID 0000-0002-3923-5195
Nigel FrenchTāwharau Ora/School of Veterinary Science, Massey University, Palmerston North, New Zealand.ORCID 0000-0002-6334-0657
David WelchDepartment of Microbiology and Immunology, University of Otago, Dunedin, New Zealand.
James HadfieldFred Hutchinson Cancer Research Centre, Seattle, Washington, USA.
Joep de LigtInstitute of Environmental Science and Research, Wellington, New Zealand.ORCID 0000-0002-0348-419X
Jemma L GeogheganInstitute of Environmental Science and Research, Wellington, New Zealand. jemma.geoghegan@otago.ac.nz.ORCID 0000-0003-0970-0153

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

New Zealand's COVID-19 elimination strategy heavily relied on the use of genomics to inform contact tracing, linking cases to the border and to clusters during community outbreaks. In August 2021, New Zealand entered its second nationwide lockdown after the detection of a single community case with no immediately apparent epidemiological link to the border. This incursion resulted in the largest outbreak seen in New Zealand caused by the Delta Variant of Concern. Here we generated 3806 high quality SARS-CoV-2 genomes from cases reported in New Zealand between 17 August and 1 December 2021, representing 43% of reported cases. We detected wide geographical spread coupled with undetected community transmission, characterised by the apparent extinction and reappearance of genomically linked clusters. We also identified the emergence, and near replacement, of genomes possessing a 10-nucleotide frameshift deletion that caused the likely truncation of accessory protein ORF7a. By early October, New Zealand moved from an elimination strategy to a suppression strategy and the role of genomics changed markedly from being used to track and trace, towards population-level surveillance.

Indexed as

COVID-19SARS-CoV-2Communicable Disease ControlGenomicsHumansNew Zealand

Identifiers

PMID35821124
PMCPMC9274967

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.