Evidence map›Paper›PMID 35821102›Full record

ReviewJournal of immunology (Baltimore, Md. : 1950)2022

Innate and Innate-like Effector Lymphocytes in Health and Disease.

Luc Van Kaer, J Luke Postoak, Wenqiang Song, Lan Wu

Abstract readReview
In one paragraph

Review in Journal of immunology (Baltimore, Md. : 1950), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Review
  6. Innateness transcriptome gradients characterize mouse T lymphocyte populations.Journal of immunology (Baltimore, Md. : 1950) · 2025
    Article
  7. Fibroblasts and immune cells: at the crossroad of organ inflammation and fibrosis.American journal of physiology. Heart and circulatory physiology · 2024
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. A spatial human thymus cell atlas mapped to a continuous tissue axis.bioRxiv : the preprint server for biology · 2023
    Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Frontiers in immunology · 2023
    Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Luc Van KaerDepartment of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN luc.van.kaer@vumc.org.ORCID 0000-0001-5275-2309
J Luke PostoakDepartment of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN.
Wenqiang SongDepartment of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN.
Lan WuDepartment of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN.

Funding

Role of autophagy-related protein Vps34 in antigen presentation and self-toleranceR01AI139046 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI VAN KAER, LUC · 2019 to 2023
$2.2M
American Heart Association-American Stroke Association 19TPA34910078NIAID NIH HHS R01 AI139046
6 · The paper itself

Abstract

Lymphocytes can be functionally partitioned into subsets belonging to the innate or adaptive arms of the immune system. Subsets of innate and innate-like lymphocytes may or may not express Ag-specific receptors of the adaptive immune system, yet they are poised to respond with innate-like speed to pathogenic insults but lack the capacity to develop classical immunological memory. These lymphocyte subsets display a number of common properties that permit them to integrate danger and stress signals dispatched by innate sensor cells to facilitate the generation of specialized effector immune responses tailored toward specific pathogens or other insults. In this review, we discuss the functions of distinct subsets of innate and innate-like lymphocytes. A better understanding of the mechanisms by which these cells are activated in different contexts, their interactions with other immune cells, and their role in health and disease may inform the development of new or improved immunotherapies.

Indexed as

Immunity, InnateLymphocytesImmunologic MemoryImmunotherapy

Identifiers

PMID35821102
PMCPMC9285656

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.