Evidence map›Paper›PMID 35821060›Full record

ArticleBreast cancer research : BCR2022

Exposure to polycyclic aromatic hydrocarbons during pregnancy and breast tissue composition in adolescent daughters and their mothers: a prospective cohort study.

Rebecca D Kehm, E Jane Walter, Sabine Oskar, Melissa L White, Parisa Tehranifar, Julie B Herbstman, Frederica Perera, Lothar Lilge, Rachel L Miller, Mary Beth Terry

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Breast cancer research : BCR, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Socioeconomic Status at Birth and Breast Tissue Composition in Adolescence and Adulthood.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2023
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Rebecca D KehmDepartment of Epidemiology, Mailman School of Public Health, Columbia University, 722 W 168th St, Room 1605, New York, NY, 10032, USA. rk2967@cumc.columbia.edu.
E Jane WalterPrincess Margaret Cancer Centre, University Health Network, 101 College St, Toronto, ON, M5G 0A3, Canada.
Sabine OskarDepartment of Epidemiology, Mailman School of Public Health, Columbia University, 722 W 168th St, Room 1605, New York, NY, 10032, USA.
Melissa L WhiteDepartment of Epidemiology, Mailman School of Public Health, Columbia University, 722 W 168th St, Room 1605, New York, NY, 10032, USA.
Parisa TehranifarDepartment of Epidemiology, Mailman School of Public Health, Columbia University, 722 W 168th St, Room 1605, New York, NY, 10032, USA.
Julie B HerbstmanDepartment of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, 10032, USA.
Frederica PereraDepartment of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, 10032, USA.
Lothar LilgePrincess Margaret Cancer Centre, University Health Network, 101 College St, Toronto, ON, M5G 0A3, Canada.
Rachel L MillerDivision of Clinical Immunology, Department of Medicine, Icahn School of Medicine at Mount Sinai, 1 Gustave L Levy Place, New York, NY, 10029, USA.
Mary Beth TerryDepartment of Epidemiology, Mailman School of Public Health, Columbia University, 722 W 168th St, Room 1605, New York, NY, 10032, USA.
Columbia University · USIcahn School of Medicine at Mount Sinai · USPrincess Margaret Cancer Centre · CAUniversity of Toronto · CA

Funding

Pregnancy and Prenatal PAHs and other Environmental Exposures and Breast CancerU01ES026122 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MILLER, RACHEL L, TERRY, MARY BETH · 2015 to 2019
$4.5M
Characterizing the role of adolescent physical activity in early onset breast cancer risk for women across the familial risk continuumK99CA263024 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI KEHM, REBECCA D · 2022 to 2023
$342k
NCI NIH HHS K99 CA263024NIEHS NIH HHS U01 ES026122
6 · The paper itself

Abstract

backgroundPolycyclic aromatic hydrocarbons (PAH), which are found in air pollution, have carcinogenic and endocrine disrupting properties that might increase breast cancer risk. PAH exposure might be particularly detrimental during pregnancy, as this is a time when the breast tissue of both the mother and daughter is undergoing structural and functional changes. In this study, we tested the hypothesis that ambient PAH exposure during pregnancy is associated with breast tissue composition, measured one to two decades later, in adolescent daughters and their mothers.

methodsWe conducted a prospective analysis using data from a New York City cohort of non-Hispanic Black and Hispanic mother-daughter dyads (recruited 1998-2006). During the third trimester of pregnancy, women wore backpacks containing a continuously operating air sampling pump for two consecutive days that measured ambient exposure to eight carcinogenic higher molecular weight nonvolatile PAH compounds (Σ8 PAH) and pyrene. When daughters (n = 186) and mothers (n = 175) reached ages 11-20 and 29-55 years, respectively, optical spectroscopy (OS) was used to evaluate measures of breast tissue composition (BTC) that positively (water content, collagen content, optical index) and negatively (lipid content) correlate with mammographic breast density, a recognized risk factor for breast cancer. Multivariable linear regression was used to evaluate associations between ambient PAH exposure and BTC, overall and by exposure to household tobacco smoke during pregnancy (yes/no). Models were adjusted for race/ethnicity, age, and percent body fat at OS.

resultsNo overall associations were found between ambient PAH exposure (Σ8 PAH or pyrene) and BTC, but statistically significant additive interactions between Σ8 PAH and household tobacco smoke exposure were identified for water content and optical index in both daughters and mothers (interaction p values < 0.05). Σ8 PAH exposure was associated with higher water content (β

conclusionsExposure to ambient Σ8 PAH and tobacco smoke during pregnancy might interact synergistically to impact BTC in mothers and daughters. If replicated in other cohorts, these findings might have important implications for breast cancer risk across generations.

Indexed as

Breast NeoplasmsPolycyclic Aromatic HydrocarbonsTobacco Smoke PollutionAdolescentBreast DensityCohort StudiesFemaleHumansMothersNuclear FamilyPregnancyProspective StudiesPyrenesWaterPolycyclic Aromatic HydrocarbonsPyrenesTobacco Smoke PollutionWaterBreast cancer riskBreast densityBreast tissue compositionEndocrine disrupting chemicalsPolycyclic aromatic hydrocarbonsTobacco smoke

Identifiers

PMID35821060
PMCPMC9277813
OpenAlexW4285095489

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.