Evidence map›Paper›PMID 35821032›Full record

ArticleJournal of biomedical science2022

Generational synaptic functions of GABA

Ming-Chia Chu, Han-Fang Wu, Chi-Wei Lee, Yueh-Jung Chung, Hsiang Chi, Po See Chen, Hui-Ching Lin

Erratum issuedOpen access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of biomedical science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. GABAFrontiers in pharmacology · 2026
    Review
  5. Article
  6. Article
  7. Article
  8. Correction: Generational synaptic functions of GABAJournal of biomedical science · 2023
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Ming-Chia ChuDepartment and Institute of Physiology, School of Medicine, National Yang Ming Chiao Tung University, Taipei, 112, Taiwan.
Han-Fang WuDepartment and Institute of Physiology, School of Medicine, National Yang Ming Chiao Tung University, Taipei, 112, Taiwan.
Chi-Wei LeeDepartment and Institute of Physiology, School of Medicine, National Yang Ming Chiao Tung University, Taipei, 112, Taiwan.
Yueh-Jung ChungDepartment and Institute of Physiology, School of Medicine, National Yang Ming Chiao Tung University, Taipei, 112, Taiwan.
Hsiang ChiDepartment and Institute of Physiology, School of Medicine, National Yang Ming Chiao Tung University, Taipei, 112, Taiwan.
Po See ChenDepartment of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, 704, Taiwan. chenps@mail.ncku.edu.tw.
Hui-Ching LinDepartment and Institute of Physiology, School of Medicine, National Yang Ming Chiao Tung University, Taipei, 112, Taiwan. hclin7@nycu.edu.tw.ORCID http://orcid.org/0000-0002-1639-9293
National Yang Ming Chiao Tung University · TWNational Cheng Kung University Hospital · TW

Funding

the Brain Research Center, National Yang Ming Chiao Tung University from The Featured Areas Research Center Program within the framework of the Higher Education Sprout Project by the Ministry of Education (MOE) in Taiwan 108BRC-B503the Brain Research Center, National Yang Ming Chiao Tung University from The Featured Areas Research Center Program within the framework of the Higher Education Sprout Project by the Ministry of Education (MOE) in Taiwan 109BRC-B503the Brain Research Center, National Yang Ming Chiao Tung University from The Featured Areas Research Center Program within the framework of the Higher Education Sprout Project by the Ministry of Education (MOE) in Taiwan 110BRC-B503the Kaohsiung Medical University-National Yang Ming Chiao Tung University Joint Research Program, Taiwan NYCUKMU-111-I008the Ministry of Science and Technology (MOST), Taiwan MOST 107-2811-B-010-519the Ministry of Science and Technology (MOST), Taiwan MOST 108-2628-B-010-004the Ministry of Science and Technology (MOST), Taiwan MOST 109-2628-B-010-003the Ministry of Science and Technology (MOST), Taiwan MOST 110-2320-B-A49A-503the Ministry of Science and Technology (MOST), Taiwan MOST 110-2628-B-A49A-504the Ministry of Science and Technology (MOST), Taiwan MOST 111-2811-B-A49A-004the National Yang Ming Chiao Tung University-Far Eastern Memorial Hospital Joint Research Program, Taiwan #NYMU-FEMH 110DN12
6 · The paper itself

Abstract

backgroundDisruption of normal brain development is implicated in numerous psychiatric disorders with neurodevelopmental origins, including autism spectrum disorder (ASD). Widespread abnormalities in brain structure and functions caused by dysregulations of neurodevelopmental processes has been recently shown to exert adverse effects across generations. An imbalance between excitatory/inhibitory (E/I) transmission is the putative hypothesis of ASD pathogenesis, supporting by the specific implications of inhibitory γ-aminobutyric acid (GABA)ergic system in autistic individuals and animal models of ASD. However, the contribution of GABAergic system in the neuropathophysiology across generations of ASD is still unknown. Here, we uncover profound alterations in the expression and function of GABA

methodsThe F2 generation was produced by mating an F1 VPA-induced male offspring with naïve females after a single injection of VPA on embryonic day (E12.5) in F0. Autism-like behaviors were assessed by animal behavior tests. Expression and functional properties of GABA

resultsSocial deficit, repetitive behavior, and emotional comorbidities were demonstrated across two generations of the VPA-induced offspring. Decreased synaptic GABA

conclusionsTaken together, these findings revealed the E/I synaptic abnormalities in the amygdala from two generations of the VPA-induced offspring with GABAergic deteriorations in the F2 generation, suggesting a potential therapeutic role of the GABAergic system to generational pathophysiology of ASD.

Indexed as

Autism Spectrum DisorderReceptors, GABA-AAnimalsDisease Models, AnimalFemalegamma-Aminobutyric AcidHumansMaleRatsSynapsesValproic Acidgamma-Aminobutyric AcidReceptors, GABA-AValproic AcidAutism spectrum disorderExcitatory/inhibitory imbalanceGABAARGenerational effectGephyrinValproate

Identifiers

PMID35821032
PMCPMC9277936
OpenAlexW4285095485

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.