Evidence map›Paper›PMID 35820861›Full record

ArticleBMC neurology2022

Height and nigral neuron density in Parkinson's disease.

Laura Saari, Emmilotta A Backman, Pia Wahlsten, Maria Gardberg, Valtteri Kaasinen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Laura SaariClinical Neurosciences, Faculty of Medicine, University of Turku, Turku, Finland. laasaa@utu.fi.
Emmilotta A BackmanClinical Neurosciences, Faculty of Medicine, University of Turku, Turku, Finland.
Pia WahlstenForensic Medicine Unit, Finnish Institute for Health and Welfare, Southwest Finland region, Helsinki, Finland.
Maria GardbergDepartment of Pathology, Turku University Hospital and Institute of Biomedicine, University of Turku, Turku, Finland.
Valtteri KaasinenClinical Neurosciences, Faculty of Medicine, University of Turku, Turku, Finland.
Turku University Hospital · FIFinnish Institute for Health and Welfare · FIUniversity of Turku · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe dopaminergic system modulates growth hormone secretion and previous results have suggested a link between short stature and an increased risk of Parkinson's disease (PD).

methodsIn 36 Lewy body spectrum disease (LBD) cases (PD = 22) and 19 controls, nigral TH-positive neuron densities were measured postmortem from midbrain sections and corrected with the Abercrombie method. Body measurements were collected from autopsies or patient records. Our aim was to investigate the possible relationship between height and the density of neurons in the substantia nigra pars compacta (SNc).

resultsSNc neuron density (n/mm

conclusionsIndividual adult height may be connected to nigral neuron numbers in patients with LBDs, including PD.

Indexed as

Lewy Body DiseaseParkinson DiseaseAdultDopamineHumansMesencephalonNeuronsSubstantia NigraDopamineHeightParkinsonismParkinson’s diseasePathologySubstantia nigra

Identifiers

PMID35820861
PMCPMC9277822
OpenAlexW4285094742

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.