ArticleBMC genomics2022
Runs of homozygosity in Sable Island feral horses reveal the genomic consequences of inbreeding and divergence from domestic breeds.
Article in BMC genomics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Runs of Homozygosity Predict Inbreeding Depression Across Taxa: A Systematic Review and Meta-Analysis.Molecular ecology · 2026Pooled it
- Advances in Equine Genomics: Decoding the Genetic Architecture of Morphology, Performance, Behavior, and Adaptation.Molecular biotechnology · 2026Review
- Integrative Advances in Equine Genomics From Reference Assemblies to Evolutionary History and Key Traits.Evolutionary applications · 2026Review
- No Pedigree, No Problem: Genomic Inbreeding Tracks Genetic Rescue With High Resolution.Evolutionary applications · 2026Article
- Comparison between SNP array and imputed data to estimate population structure and ROH hotspots in horse breeds.BMC genomics · 2025Article
- Fine-scale assessment of ROH patterns and genomic inbreeding in diverse horse breeds using two SNP array densities.BMC veterinary research · 2025Article
- Characterisation of the Historic Demographic Decline of the British European Polecat Population.Molecular ecology · 2025Article
- Genomic Analysis Reveals Inbreeding in an Island Population of Alexander Archipelago Wolves.Evolutionary applications · 2025Article
- Genomic architecture of purebred and crossbred Moghani lambs with Texel and Booroola sheep.Scientific reports · 2025Article
- Genomic consequences of intensive inbreeding in miniature inbred pigs.BMC genomics · 2025Article
- Rewilded horses in European nature conservation - a genetics, ethics, and welfare perspective.Biological reviews of the Cambridge Philosophical Society · 2025Review
- Runs of Homozygosity and Inferences in Wild Populations.Molecular ecology · 2025Review
- The genetic demographic history of the last hunter-gatherer population of the Himalayas.Scientific reports · 2025Article
- Genomic Insights Into Red Squirrels in Scotland Reveal Loss of Heterozygosity Associated With Extreme Founder Effects.Evolutionary applications · 2025Article
- Comparative Analysis of Runs of Homozygosity Islands in Indigenous and Commercial Chickens Revealed Candidate Loci for Disease Resistance and Production Traits.Veterinary medicine and science · 2025Article
- Article
- Genetic diversity and signatures of selection in Icelandic horses and Exmoor ponies.BMC genomics · 2024Article
- Genomic Consequences of Isolation and Inbreeding in an Island Dingo Population.Genome biology and evolution · 2024Article
- Genomic consequences of isolation and inbreeding in an island dingo population.bioRxiv : the preprint server for biology · 2024Article
- Runs of Homozygosity Detection and Selection Signature Analysis for Local Goat Breeds in Yunnan, China.Genes · 2024Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundUnderstanding inbreeding and its impact on fitness and evolutionary potential is fundamental to species conservation and agriculture. Long stretches of homozygous genotypes, known as runs of homozygosity (ROH), result from inbreeding and their number and length can provide useful population-level information on inbreeding characteristics and locations of signatures of selection. However, the utility of ROH for conservation is limited for natural populations where baseline data and genomic tools are lacking. Comparing ROH metrics in recently feral vs. domestic populations of well understood species like the horse could provide information on the genetic health of those populations and offer insight into how such metrics compare between managed and unmanaged populations. Here we characterized ROH, inbreeding coefficients, and ROH islands in a feral horse population from Sable Island, Canada, using ~41 000 SNPs and contrasted results with those from 33 domestic breeds to assess the impacts of isolation on ROH abundance, length, distribution, and ROH islands.
resultsROH number, length, and ROH-based inbreeding coefficients (F
conclusionsThis study indicates that Sable Island horses tend to be more inbred than their domestic counterparts and that most of this inbreeding is due to historical bottlenecks and founder effects rather than recent mating between close relatives. Unique ROH islands in the Sable Island population suggest adaptation to local selective pressures and/or strong genetic drift and highlight the value of this population as a reservoir of equine genetic variation. This research illustrates how ROH analyses can be applied to gain insights into the population history, genetic health, and divergence of wild or feral populations of conservation concern.
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