ArticleBMC plant biology2022
Transcription-associated metabolomic profiling reveals the critical role of frost tolerance in wheat.
Article in BMC plant biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 46 citations in OpenAlex.
- ABA Accumulation Confers Cross-Adaptation to Saline-Alkali and Cold Stresses in Alfalfa.Plant, cell & environment · 2026Article
- Deciphering Cold Stress Resilience: Multiomics Insights in Contrasting Wheat Genotypes From the Western Himalayas.Plant biotechnology journal · 2026Article
- Genetic dissection of cold stress tolerance and yield potential under cold stress in nested synthetic wheat (Triticum aestivum L.) introgression libraries using multi-locus genome-wide association and haplotype analysis.Functional & integrative genomics · 2026Article
- Chemotaxis to plant defense compounds in phytopathogens.PLoS pathogens · 2026Article
- Integrated transcriptomic and metabolomic identification of the core pathway of photosynthetic carbon fixation in mung bean under saline-alkali stress.Frontiers in plant science · 2026Article
- Integrated physiological, transcriptomic and metabolomic analysis reveals differential cold response in wheat seedlings across varieties.Frontiers in plant science · 2026Article
- Transcriptomic and metabolomic analysis of tobacco responses to combined organic-chemical fertilization.BMC plant biology · 2025Article
- Integrated Metabolomics and Transcriptomics Analyses Reveal the Critical Role of Caffeic Acid in Potato (Plants (Basel, Switzerland) · 2025Article
- Dynamic transcriptomic and metabolomic adaptation mechanisms of Trifolium ambiguum under different durations of cold stress.Scientific reports · 2025Article
- Integrated analysis of transcriptomic and metabolomic reveal insights into low-temperature stress in sainfoin (Onobrychis viciifolia) seedlings.BMC plant biology · 2025Article
- Review
- Multi-omics analysis reveals the physiological and molecular response to cold stress in different spring wheat cultivars at the booting stage.Frontiers in plant science · 2025Article
- Integrated transcriptome and metabolome analyses reveals the mechanisms of function loss ofFrontiers in plant science · 2025Article
- Metabolome and transcriptome analyses reveal molecular responses of two potato (Frontiers in plant science · 2025Article
- Cold stress adaptation inFrontiers in plant science · 2025Article
- Physiological and molecular regulatory mechanism of flavonoid metabolite biosynthesis during low temperature adaptation in Lavandula angustifolia Mill.BMC plant biology · 2024Article
- Metabolomics and transcriptomics combined with physiology reveal key metabolic pathway responses in tobacco roots exposed to NaHS.BMC plant biology · 2024Article
- Deacclimation and reacclimation processes in winter wheat: novel perspectives from time-series transcriptome analysis.Frontiers in plant science · 2024Article
- Molecular mapping of two novel cold resistance genes in common wheat by 660K SNP array.Molecular breeding : new strategies in plant improvement · 2023Article
- Metabolomics-based exploration the response mechanisms of Saussurea involucrata leaves under different levels of low temperature stress.BMC genomics · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLow temperature is a crucial stress factor of wheat (Triticum aestivum L.) and adversely impacts on plant growth and grain yield. Multi-million tons of grain production are lost annually because crops lack the resistance to survive in winter. Particularlly, winter wheat yields was severely damaged under extreme cold conditions. However, studies about the transcriptional and metabolic mechanisms underlying cold stresses in wheat are limited so far.
resultsIn this study, 14,466 differentially expressed genes (DEGs) were obtained between wild-type and cold-sensitive mutants, of which 5278 DEGs were acquired after cold treatment. 88 differential accumulated metabolites (DAMs) were detected, including P-coumaroyl putrescine of alkaloids, D-proline betaine of mino acids and derivativ, Chlorogenic acid of the Phenolic acids. The comprehensive analysis of metabolomics and transcriptome showed that the cold resistance of wheat was closely related to 13 metabolites and 14 key enzymes in the flavonol biosynthesis pathway. The 7 enhanced energy metabolites and 8 up-regulation key enzymes were also compactly involved in the sucrose and amino acid biosynthesis pathway. Moreover, quantitative real-time PCR (qRT-PCR) revealed that twelve key genes were differentially expressed under cold, indicating that candidate genes POD, Tacr7, UGTs, and GSTU6 which were related to cold resistance of wheat.
conclusionsIn this study, we obtained the differentially expressed genes and differential accumulated metabolites in wheat under cold stress. Using the DEGs and DAMs, we plotted regulatory pathway maps of the flavonol biosynthesis pathway, sucrose and amino acid biosynthesis pathway related to cold resistance of wheat. It was found that candidate genes POD, Tacr7, UGTs and GSTU6 are related to cold resistance of wheat. This study provided valuable molecular information and new genetic engineering clues for the further study on plant resistance to cold stress.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.