Evidence map›Paper›PMID 35820799›Full record

ArticleThe journal of headache and pain2022

Visual stimulation and frequency of focal neurological symptoms engage distinctive neurocognitive resources in migraine with aura patients: a study of resting-state functional networks.

Gianluca Coppola, Ilenia Corbelli, Antonio Di Renzo, Andrea Chiappiniello, Pietro Chiarini, Vincenzo Parisi, Giorgio Guercini, Paolo Calabresi, Roberto Tarducci, Paola Sarchielli

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of headache and pain, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Hallmarks of primary headache: part 1 - migraine.The journal of headache and pain · 2024
    Review
  5. Article
  6. Article
  7. Evaluating migraine with typical aura with neuroimaging.Frontiers in human neuroscience · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 1 country.

Gianluca Coppola *Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome Polo Pontino - I.C.O.T., Via Franco Faggiana 1668, 04100, Latina, Italy. gianluca.coppola@uniroma1.it.
Ilenia Corbelli *Section of Neurology, Department of Medicine and Surgery, University of Perugia, Perugia, Italy.
Antonio Di RenzoIRCCS - Fondazione Bietti, Rome, Italy.
Andrea ChiappinielloMedical Physics Service, Azienda Ospedaliera Di Perugia, Perugia, Italy.
Pietro ChiariniMedical Physics Service, Azienda Ospedaliera Di Perugia, Perugia, Italy.
Vincenzo ParisiIRCCS - Fondazione Bietti, Rome, Italy.
Giorgio GuerciniNeuroradiology Service, Azienda Ospedaliera Di Perugia, Perugia, Italy.
Paolo CalabresiDepartment of Neuroscience, Cattolica Sacro Cuore University, Rome, Italy.
Roberto TarducciMedical Physics Service, Azienda Ospedaliera Di Perugia, Perugia, Italy.
Paola SarchielliSection of Neurology, Department of Medicine and Surgery, University of Perugia, Perugia, Italy.
Azienda Ospedaliera di Perugia · ITUniversity of Perugia · ITFondazione G.B. Bietti · ITIstituti di Ricovero e Cura a Carattere Scientifico · ITSapienza University of Rome · ITUniversità Cattolica del Sacro Cuore · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionSeveral functional neuroimaging studies on healthy controls and patients with migraine with aura have shown that the activation of functional networks during visual stimulation is not restricted to the striate system, but also includes several extrastriate networks.

methodsBefore and after 4 min of visual stimulation with a checkerboard pattern, we collected functional MRI in 21 migraine with aura (MwA) patients and 18 healthy subjects (HS). For each recording session, we identified independent resting-state networks in each group and correlated network connection strength changes with clinical disease features.

resultsBefore visual stimulation, we found reduced connectivity between the default mode network and the left dorsal attention system (DAS) in MwA patients compared to HS. In HS, visual stimulation increases functional connectivity between the independent components of the bilateral DAS and the executive control network (ECN). In MwA, visual stimulation significantly improved functional connectivity between the independent component pairs salience network and DAS, and between DAS and ECN. The ECN Z-scores after visual stimulation were negatively related to the monthly frequency of aura.

conclusionsIn individuals with MwA, 4 min of visual stimulation had stronger cognitive impact than in healthy people. A higher frequency of aura may lead to a diminished ability to obtain cognitive resources to cope with transitory but important events like aura-related focal neurological symptoms.

Indexed as

EpilepsyMigraine with AuraBrain MappingHumansMagnetic Resonance ImagingPhotic StimulationAttentive systemsAuraDecision-makingExecutive control networkSalience network

Identifiers

PMID35820799
PMCPMC9277919
OpenAlexW4285091576

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.