Evidence map›Paper›PMID 35820757›Full record

ArticleBMJ open2022

Effect of Zhan Zhuang Qigong on upper limb static tremor and aerobic exercise capacity in patients with mild-to-moderate Parkinson's disease: study protocol for a randomised controlled trial.

Linlin Zhang, Xihua Liu, Xiaoming Xi, Yuxiao Chen, Qing Wang, Xinjie Qu, Haihao Cao, Limin Wang, Wenyu Sun, Guoming Chen and 5 more

Open access · goldAbstract readClinical Trial Protocol
In one paragraph

Article in BMJ open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. A novel pulsed field ablation system using linear and spiral ablation catheters can create large and durable endocardial and epicardial ventricular lesions in vivo.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Linlin ZhangShandong University of Traditional Chinese Medicine, Jinan, china.ORCID 0000-0002-7692-087X
Xihua LiuShandong University of Traditional Chinese Medicine Affiliated Hospital, Jinan, Shandong, China.
Xiaoming XiShandong University of Traditional Chinese Medicine, Jinan, china.
Yuxiao ChenShandong University of Traditional Chinese Medicine, Jinan, china.
Qing WangShandong University of Traditional Chinese Medicine, Jinan, china.
Xinjie QuShandong University of Traditional Chinese Medicine, Jinan, china.
Haihao CaoShandong University of Traditional Chinese Medicine, Jinan, china.
Limin WangShandong University of Traditional Chinese Medicine, Jinan, china.
Wenyu SunShandong University of Traditional Chinese Medicine Affiliated Hospital, Jinan, Shandong, China.
Guoming ChenShandong University of Traditional Chinese Medicine Affiliated Hospital, Jinan, Shandong, China.
Huifen LiuShandong University of Traditional Chinese Medicine, Jinan, china.
Xiaoyu JiangShandong University of Traditional Chinese Medicine, Jinan, china.
Hang SuShandong University of Traditional Chinese Medicine, Jinan, china.
Jiahui JiangShandong University of Traditional Chinese Medicine, Jinan, china.
Hongyan BiShandong University of Traditional Chinese Medicine Affiliated Hospital, Jinan, Shandong, China Hy__bi@163.com.
Shandong University of Traditional Chinese Medicine · CNAffiliated Hospital of Shandong University of Traditional Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionCurrently, the first choice for the clinical treatment of static tremor in Parkinson's disease (PD) is drug therapy, however side effects are common. In recent years, the effects of physical therapy on PD has become a serious research focus. Studies have indicated that aerobic and resistance exercises alleviate PD movement disorders and improve aerobic capacity, but the effects of Qigong on PD static tremor and aerobic capacity remain unknown. METHODS AND ANALYSIS:

objectiveTo observe the effects of Zhan Zhuang Qigong on upper limb static tremor and aerobic capacity in patients with PD, we established a rigorous randomised, parallel-controlled, assignment hidden, evaluator-blinded protocol.

methodsSeventy-two patients with PD, at the Affiliated Hospital of Shandong University of Traditional Chinese Medicine, were recruited and randomly divided into a control (n=36) and experimental group (n=36). The intervention group received conventional medicine plus Zhan Zhuang Qigong exercises five times a week at 30 min each time, over an 8-week period. The long-term effects of Zhan Zhuang Qigong on PD was investigated after the intervention. Phyphox APP, CRST, CPET, UPDRS(II, III) were used to evaluate tremor, aerobic capacity, and motor function in groups. DISCUSSION: We are investigating the effects of Zhan Zhuang Qigong on upper limb static tremor and aerobic capacity in patients with PD. If positive are identified, they will add a new research direction and evidence for the clinical exploration of exercise therapy for PD. ETHICS AND DISSEMINATION: This study was approved by the Ethics Committee of Shandong University of Traditional Chinese Medicine (Approval Number: 2021-025-KY). The Committee will be informed of any changes to the trial protocol, such as intervention intensity, outcome indicators and data collection. Study results will be presented as a paper at an international conference or in a journal. TRIAL REGISTRATION NUMBER: ChiCTR2100053529.

Indexed as

Parkinson DiseaseQigongExerciseHumansQuality of LifeRandomized Controlled Trials as TopicTremorUpper ExtremityClinical trialsGERIATRIC MEDICINEParkinson-s diseaseRehabilitation medicine

Identifiers

PMID35820757
PMCPMC9274526
OpenAlexW4285099052

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.