Evidence map›Paper›PMID 35820756›Full record

ArticleBMJ open2022

Prospective surveillance study to detect antimalarial drug resistance, gene deletions of diagnostic relevance and genetic diversity of

Alfredo Mayor, Clemente da Silva, Eduard Rovira-Vallbona, Arantxa Roca-Feltrer, Craig Bonnington, Alexandra Wharton-Smith, Bryan Greenhouse, Caitlin Bever, Arlindo Chidimatembue, Caterina Guinovart and 9 more

Registry-linked trialAbstract readClinical Trial Protocol
In one paragraph

Article in BMJ open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05306067 (A Prospective Surveillance Study to Detect Antimalarial Drug Resistance, Gene Deletions of Diagnostic Relevance and Genetic Diversity of Plasmodium Falciparum in Mozambique), which is not on this map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05306067 completednot on this map

A Prospective Surveillance Study to Detect Antimalarial Drug Resistance, Gene Deletions of Diagnostic Relevance and Genetic Diversity of Plasmodium Falciparum in Mozambique

TypeobservationalSponsorCentro de Investigacao em Saude de ManhicaRan2021 to 2024Enrolled21,848ConditionsMalaria,Falciparum, Malaria in Pregnancy, MalariaArmsLDH-based malaria rapid diagnostic test, Malaria rapid diagnostic test
3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
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  3. Article
  4. Article
  5. Review
  6. BMJ open · 2024
    Observational
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  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Alfredo MayorCentro de Investigação em Saúde de Manhiça, Manhiça, Maputo, Mozambique alfredo.mayor@isglobal.org.ORCID 0000-0003-3890-2897
Clemente da SilvaCentro de Investigação em Saúde de Manhiça, Manhiça, Maputo, Mozambique.
Eduard Rovira-VallbonaBarcelona Institute for Global Health, Hospital Clínic-Universitat de Barcelona, Barcelona, Spain.
Arantxa Roca-FeltrerMalaria Consortium, London, UK.
Craig BonningtonMalaria Consortium, London, UK.
Alexandra Wharton-SmithMalaria Consortium, London, UK.
Bryan GreenhouseDepartment of Medicine, University of California San Francisco, San Francisco, California, USA.
Caitlin BeverBill & Melinda Gates Foundation, Seattle, Washington, USA.
Arlindo ChidimatembueCentro de Investigação em Saúde de Manhiça, Manhiça, Maputo, Mozambique.
Caterina GuinovartBarcelona Institute for Global Health, Hospital Clínic-Universitat de Barcelona, Barcelona, Spain.
Joshua L ProctorBill & Melinda Gates Foundation, Seattle, Washington, USA.
Maria RodriguesMalaria Consortium, London, UK.
Neide CananaMalaria Consortium, London, UK.
Paulo ArnaldoInstituto Nacional de Saúde, Maputo, Mozambique.
Simone BoeneCentro de Investigação em Saúde de Manhiça, Manhiça, Maputo, Mozambique.
Pedro AideCentro de Investigação em Saúde de Manhiça, Manhiça, Maputo, Mozambique.
Sonia EnosseMalaria Consortium, London, UK.
Francisco SauteCentro de Investigação em Saúde de Manhiça, Manhiça, Maputo, Mozambique.
Baltazar CandrinhoMinistry of Health, Maputo, Mozambique.

Funding

Mentoring translational scientists in international infectious disease researchK24AI144048 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Bryan R Greenhouse · 2019 to 2026
$1.6M
Translational Studies of Plasmodium Falciparum Infection DynamicsK23AI076614 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GREENHOUSE, BRYAN R · 2008 to 2012
$609k
Gates Foundation INV-019032NIAID NIH HHS K23 AI076614NIAID NIH HHS K24 AI144048
6 · The paper itself

Abstract

introductionGenomic data constitute a valuable adjunct to routine surveillance that can guide programmatic decisions to reduce the burden of infectious diseases. However, genomic capacities remain low in Africa. This study aims to operationalise a functional malaria molecular surveillance system in Mozambique for guiding malaria control and elimination. METHODS AND ANALYSES: This prospective surveillance study seeks to generate ETHICS AND DISSEMINATION: The protocol was reviewed and approved by the institutional (CISM) and national ethics committees of Mozambique (Comité Nacional de Bioética para Saúde) and Spain (Hospital Clinic of Barcelona). Project results will be presented to all stakeholders and published in open-access journals. TRIAL REGISTRATION NUMBER: NCT05306067.

Indexed as

AntimalarialsMalariaDrug ResistanceFemaleGene DeletionHumansMozambiqueMulticenter Studies as TopicPlasmodium falciparumPregnancyProspective StudiesAntimalarialsEpidemiologyGeneticsMOLECULAR BIOLOGYMolecular diagnosticsPARASITOLOGYPublic health

Identifiers

PMID35820756
PMCPMC9274532

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.