ArticleThoracic cancer2022
Comparison of clinical results between high grade patterns in stage I lung adenocarcinoma.
Article in Thoracic cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Article
- Optimizing surgical decision-making for lung adenocarcinoma by preoperatively identifying pathological high-risk factors: retrospective development and prospective validation of a deep learning model.International journal of surgery (London, England) · 2026Article
- Visceral Pleural Invasion as a Determinant of Surgical Strategy in Non-Small Cell Lung Cancer: A Multicenter Study.Cancers · 2025Article
- Novel Insights Into the International Association for the Study of Lung Cancer Grading System for Lung Adenocarcinoma.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2024Article
- Cancer cell immunity-related protein co-expression networks are associated with early-stage solid-predominant lung adenocarcinoma.Frontiers in oncology · 2024Article
- Lung adenocarcinoma with micropapillary and solid patterns: Recurrence rate and trends.Thoracic cancer · 2023Article
- Relationship between PD-L1 expression and molecular aberrances in lung adenocarcinoma with solid components.Journal of thoracic disease · 2023Article
- Comparison of clinical results between high grade patterns in stage I lung adenocarcinoma.Thoracic cancer · 2022Article
- Risk analysis of visceral pleural invasion in malignant solitary pulmonary nodules that appear touching the pleural surface.Therapeutic advances in respiratory diseaseArticle
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Authors and funding
4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundThe histological subtype has been introduced in invasive lung adenocarcinoma. The predominant micropapillary and solid subtypes are categorized as high-grade patterns and provide a worse prognosis. However, the prognostic analysis of high-grade patterns has not previously been fully investigated. Thus, this study aimed to investigate the prognostic role of high-grade patterns in pathological stage I lung adenocarcinoma.
methodsPatients with stage I lung adenocarcinoma and micropapillary or solid components were reviewed. Clinicopathological features and clinical course were compared in these subtypes, and prognostic factors were analyzed in high-grade patterns.
resultsThe patients were classified into five groups based on the presence of micropapillary or solid subtypes, namely, micropapillary predominant, solid predominant, both nonpredominant subtypes, only minor micropapillary subtype, and only minor solid subtype present. Disease-free interval was significantly different, and the micropapillary predominant group showed worse disease-free interval (p = 0.001). Contrastingly, the solid predominant group showed significantly worse overall survival among high-grade patterns (p = 0.035). The multivariate analysis revealed an association between smoking, micropapillary predominant, blood vessel invasion, and visceral pleural invasion with recurrence and more association between solid predominant and visceral pleural invasion with overall survival.
conclusionsClinical results were different in stage I high-grade adenocarcinoma. The predominant micropapillary subtype is the independent prognostic factor for recurrence. However, the solid subtype is the significant factor for overall survival. Furthermore, the predominant subtype is the most valuable and independent prognostic factor for predicting recurrence or survival.
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