Evidence map›Paper›PMID 35820696›Full record

SynthesisCanadian journal of surgery. Journal canadien de chirurgie

Mechanical versus bioprosthetic valves in chronic dialysis: a systematic review and meta-analysis.

Kevin S Kim, Emilie P Belley-Côté, Saurabh Gupta, Arjun Pandey, Ali Alsagheir, Ahmad Makhdoum, Graham McClure, Brooke Newsome, Sophie W Gao, Matthias Bossard and 6 more

Abstract readMeta-AnalysisSystematic Review

PubMed Full text at PMC Publisher

In one paragraph

Synthesis in Canadian journal of surgery. Journal canadien de chirurgie. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it

0cells of the map it votes in

9citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

Concomitant Aortic Valve Neocuspidization and Resection of a Cardiac Calcified Amorphous Tumor in a Hemodialysis Patient: A Case Report.Cureus · 2026
Article
Impact of Improved End-Stage Renal Disease Patient Survival on Prosthetic Valve Selection in Aortic Valve Replacement: A Nationwide Cohort Analysis.Journal of clinical medicine · 2026
Article
Procedural and Device Neutrality of Post-TAVI Renal Outcomes: A Multivariable Analysis of Valve Type, Size, and Anatomy.Journal of clinical medicine · 2026
Article
Association of Renal Impairment Severity with Surgical Outcomes in Patients with Infective Endocarditis.Current cardiology reviews · 2026
Article
Black Patients Experience Higher Complication Burden and Distinct Valve Selection Patterns in Aortic Valve Replacement.Cureus · 2026
Article
Burden of Valvular Heart Disease Diagnosed on Protocolised Echocardiography for Waitlist Placement in End-Stage Kidney Patients.Nephrology (Carlton, Vic.) · 2025
Article
Pioglitazone treatment mitigates cardiovascular bioprosthetic degeneration in a chronic kidney disease model.Frontiers in pharmacology · 2024
Article
Left atrial Thrombus formation after discontinuation of anticoagulation in patient with severe bioprosthetic mitral stenosis.BMC cardiovascular disorders · 2023
Review
Valve positions upon which cardiac surgeons operate should be taken into consideration.Canadian journal of surgery. Journal canadien de chirurgie
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Kevin S KimFrom the Michael G. DeGroote School of Medicine (Kim, Pandey); Department of Health Research Methodology, Evidence, and Impact (Kim, Gupta, Alsagheir, Makhdoum, Walsh, Garg, Guyatt, Whitlock); the Population Health Research Institute (Kim, Belley-Côté, Walsh, Whitlock); Department of Medicine (Belley-Côté, Walsh, Guyatt); Division of Cardiac Surgery (Gupta, Alsagheir, Gao, Whitlock), McMaster University, Hamilton, Ont.; Division of Cardiac Surgery (Makhdoum), University of Toronto, Toronto, Ont.; the Division of Vascular Surgery (McClure), McMaster University, Hamilton, Ont; Faculty of Health Sciences (Newsome), McMaster University, Hamilton, Ont.; Division of Cardiology (Bossard), Heart Center Luzerner Kantonsspital, Luzern, Switzerland; Division of Neonatology (Isayama, Ikuta), National Center for Child Health and Development, Tokyo, Japan; Department of Medicine (Garg), Western University, London, Ont.

Emilie P Belley-CôtéFrom the Michael G. DeGroote School of Medicine (Kim, Pandey); Department of Health Research Methodology, Evidence, and Impact (Kim, Gupta, Alsagheir, Makhdoum, Walsh, Garg, Guyatt, Whitlock); the Population Health Research Institute (Kim, Belley-Côté, Walsh, Whitlock); Department of Medicine (Belley-Côté, Walsh, Guyatt); Division of Cardiac Surgery (Gupta, Alsagheir, Gao, Whitlock), McMaster University, Hamilton, Ont.; Division of Cardiac Surgery (Makhdoum), University of Toronto, Toronto, Ont.; the Division of Vascular Surgery (McClure), McMaster University, Hamilton, Ont; Faculty of Health Sciences (Newsome), McMaster University, Hamilton, Ont.; Division of Cardiology (Bossard), Heart Center Luzerner Kantonsspital, Luzern, Switzerland; Division of Neonatology (Isayama, Ikuta), National Center for Child Health and Development, Tokyo, Japan; Department of Medicine (Garg), Western University, London, Ont.

Saurabh GuptaFrom the Michael G. DeGroote School of Medicine (Kim, Pandey); Department of Health Research Methodology, Evidence, and Impact (Kim, Gupta, Alsagheir, Makhdoum, Walsh, Garg, Guyatt, Whitlock); the Population Health Research Institute (Kim, Belley-Côté, Walsh, Whitlock); Department of Medicine (Belley-Côté, Walsh, Guyatt); Division of Cardiac Surgery (Gupta, Alsagheir, Gao, Whitlock), McMaster University, Hamilton, Ont.; Division of Cardiac Surgery (Makhdoum), University of Toronto, Toronto, Ont.; the Division of Vascular Surgery (McClure), McMaster University, Hamilton, Ont; Faculty of Health Sciences (Newsome), McMaster University, Hamilton, Ont.; Division of Cardiology (Bossard), Heart Center Luzerner Kantonsspital, Luzern, Switzerland; Division of Neonatology (Isayama, Ikuta), National Center for Child Health and Development, Tokyo, Japan; Department of Medicine (Garg), Western University, London, Ont.

Arjun PandeyFrom the Michael G. DeGroote School of Medicine (Kim, Pandey); Department of Health Research Methodology, Evidence, and Impact (Kim, Gupta, Alsagheir, Makhdoum, Walsh, Garg, Guyatt, Whitlock); the Population Health Research Institute (Kim, Belley-Côté, Walsh, Whitlock); Department of Medicine (Belley-Côté, Walsh, Guyatt); Division of Cardiac Surgery (Gupta, Alsagheir, Gao, Whitlock), McMaster University, Hamilton, Ont.; Division of Cardiac Surgery (Makhdoum), University of Toronto, Toronto, Ont.; the Division of Vascular Surgery (McClure), McMaster University, Hamilton, Ont; Faculty of Health Sciences (Newsome), McMaster University, Hamilton, Ont.; Division of Cardiology (Bossard), Heart Center Luzerner Kantonsspital, Luzern, Switzerland; Division of Neonatology (Isayama, Ikuta), National Center for Child Health and Development, Tokyo, Japan; Department of Medicine (Garg), Western University, London, Ont.

Ali AlsagheirFrom the Michael G. DeGroote School of Medicine (Kim, Pandey); Department of Health Research Methodology, Evidence, and Impact (Kim, Gupta, Alsagheir, Makhdoum, Walsh, Garg, Guyatt, Whitlock); the Population Health Research Institute (Kim, Belley-Côté, Walsh, Whitlock); Department of Medicine (Belley-Côté, Walsh, Guyatt); Division of Cardiac Surgery (Gupta, Alsagheir, Gao, Whitlock), McMaster University, Hamilton, Ont.; Division of Cardiac Surgery (Makhdoum), University of Toronto, Toronto, Ont.; the Division of Vascular Surgery (McClure), McMaster University, Hamilton, Ont; Faculty of Health Sciences (Newsome), McMaster University, Hamilton, Ont.; Division of Cardiology (Bossard), Heart Center Luzerner Kantonsspital, Luzern, Switzerland; Division of Neonatology (Isayama, Ikuta), National Center for Child Health and Development, Tokyo, Japan; Department of Medicine (Garg), Western University, London, Ont.

Ahmad MakhdoumFrom the Michael G. DeGroote School of Medicine (Kim, Pandey); Department of Health Research Methodology, Evidence, and Impact (Kim, Gupta, Alsagheir, Makhdoum, Walsh, Garg, Guyatt, Whitlock); the Population Health Research Institute (Kim, Belley-Côté, Walsh, Whitlock); Department of Medicine (Belley-Côté, Walsh, Guyatt); Division of Cardiac Surgery (Gupta, Alsagheir, Gao, Whitlock), McMaster University, Hamilton, Ont.; Division of Cardiac Surgery (Makhdoum), University of Toronto, Toronto, Ont.; the Division of Vascular Surgery (McClure), McMaster University, Hamilton, Ont; Faculty of Health Sciences (Newsome), McMaster University, Hamilton, Ont.; Division of Cardiology (Bossard), Heart Center Luzerner Kantonsspital, Luzern, Switzerland; Division of Neonatology (Isayama, Ikuta), National Center for Child Health and Development, Tokyo, Japan; Department of Medicine (Garg), Western University, London, Ont.

Graham McClureFrom the Michael G. DeGroote School of Medicine (Kim, Pandey); Department of Health Research Methodology, Evidence, and Impact (Kim, Gupta, Alsagheir, Makhdoum, Walsh, Garg, Guyatt, Whitlock); the Population Health Research Institute (Kim, Belley-Côté, Walsh, Whitlock); Department of Medicine (Belley-Côté, Walsh, Guyatt); Division of Cardiac Surgery (Gupta, Alsagheir, Gao, Whitlock), McMaster University, Hamilton, Ont.; Division of Cardiac Surgery (Makhdoum), University of Toronto, Toronto, Ont.; the Division of Vascular Surgery (McClure), McMaster University, Hamilton, Ont; Faculty of Health Sciences (Newsome), McMaster University, Hamilton, Ont.; Division of Cardiology (Bossard), Heart Center Luzerner Kantonsspital, Luzern, Switzerland; Division of Neonatology (Isayama, Ikuta), National Center for Child Health and Development, Tokyo, Japan; Department of Medicine (Garg), Western University, London, Ont.

Brooke NewsomeFrom the Michael G. DeGroote School of Medicine (Kim, Pandey); Department of Health Research Methodology, Evidence, and Impact (Kim, Gupta, Alsagheir, Makhdoum, Walsh, Garg, Guyatt, Whitlock); the Population Health Research Institute (Kim, Belley-Côté, Walsh, Whitlock); Department of Medicine (Belley-Côté, Walsh, Guyatt); Division of Cardiac Surgery (Gupta, Alsagheir, Gao, Whitlock), McMaster University, Hamilton, Ont.; Division of Cardiac Surgery (Makhdoum), University of Toronto, Toronto, Ont.; the Division of Vascular Surgery (McClure), McMaster University, Hamilton, Ont; Faculty of Health Sciences (Newsome), McMaster University, Hamilton, Ont.; Division of Cardiology (Bossard), Heart Center Luzerner Kantonsspital, Luzern, Switzerland; Division of Neonatology (Isayama, Ikuta), National Center for Child Health and Development, Tokyo, Japan; Department of Medicine (Garg), Western University, London, Ont.

Sophie W GaoFrom the Michael G. DeGroote School of Medicine (Kim, Pandey); Department of Health Research Methodology, Evidence, and Impact (Kim, Gupta, Alsagheir, Makhdoum, Walsh, Garg, Guyatt, Whitlock); the Population Health Research Institute (Kim, Belley-Côté, Walsh, Whitlock); Department of Medicine (Belley-Côté, Walsh, Guyatt); Division of Cardiac Surgery (Gupta, Alsagheir, Gao, Whitlock), McMaster University, Hamilton, Ont.; Division of Cardiac Surgery (Makhdoum), University of Toronto, Toronto, Ont.; the Division of Vascular Surgery (McClure), McMaster University, Hamilton, Ont; Faculty of Health Sciences (Newsome), McMaster University, Hamilton, Ont.; Division of Cardiology (Bossard), Heart Center Luzerner Kantonsspital, Luzern, Switzerland; Division of Neonatology (Isayama, Ikuta), National Center for Child Health and Development, Tokyo, Japan; Department of Medicine (Garg), Western University, London, Ont.

Matthias BossardFrom the Michael G. DeGroote School of Medicine (Kim, Pandey); Department of Health Research Methodology, Evidence, and Impact (Kim, Gupta, Alsagheir, Makhdoum, Walsh, Garg, Guyatt, Whitlock); the Population Health Research Institute (Kim, Belley-Côté, Walsh, Whitlock); Department of Medicine (Belley-Côté, Walsh, Guyatt); Division of Cardiac Surgery (Gupta, Alsagheir, Gao, Whitlock), McMaster University, Hamilton, Ont.; Division of Cardiac Surgery (Makhdoum), University of Toronto, Toronto, Ont.; the Division of Vascular Surgery (McClure), McMaster University, Hamilton, Ont; Faculty of Health Sciences (Newsome), McMaster University, Hamilton, Ont.; Division of Cardiology (Bossard), Heart Center Luzerner Kantonsspital, Luzern, Switzerland; Division of Neonatology (Isayama, Ikuta), National Center for Child Health and Development, Tokyo, Japan; Department of Medicine (Garg), Western University, London, Ont.

Tetsuya IsayamaFrom the Michael G. DeGroote School of Medicine (Kim, Pandey); Department of Health Research Methodology, Evidence, and Impact (Kim, Gupta, Alsagheir, Makhdoum, Walsh, Garg, Guyatt, Whitlock); the Population Health Research Institute (Kim, Belley-Côté, Walsh, Whitlock); Department of Medicine (Belley-Côté, Walsh, Guyatt); Division of Cardiac Surgery (Gupta, Alsagheir, Gao, Whitlock), McMaster University, Hamilton, Ont.; Division of Cardiac Surgery (Makhdoum), University of Toronto, Toronto, Ont.; the Division of Vascular Surgery (McClure), McMaster University, Hamilton, Ont; Faculty of Health Sciences (Newsome), McMaster University, Hamilton, Ont.; Division of Cardiology (Bossard), Heart Center Luzerner Kantonsspital, Luzern, Switzerland; Division of Neonatology (Isayama, Ikuta), National Center for Child Health and Development, Tokyo, Japan; Department of Medicine (Garg), Western University, London, Ont.

Yasuhisa IkutaFrom the Michael G. DeGroote School of Medicine (Kim, Pandey); Department of Health Research Methodology, Evidence, and Impact (Kim, Gupta, Alsagheir, Makhdoum, Walsh, Garg, Guyatt, Whitlock); the Population Health Research Institute (Kim, Belley-Côté, Walsh, Whitlock); Department of Medicine (Belley-Côté, Walsh, Guyatt); Division of Cardiac Surgery (Gupta, Alsagheir, Gao, Whitlock), McMaster University, Hamilton, Ont.; Division of Cardiac Surgery (Makhdoum), University of Toronto, Toronto, Ont.; the Division of Vascular Surgery (McClure), McMaster University, Hamilton, Ont; Faculty of Health Sciences (Newsome), McMaster University, Hamilton, Ont.; Division of Cardiology (Bossard), Heart Center Luzerner Kantonsspital, Luzern, Switzerland; Division of Neonatology (Isayama, Ikuta), National Center for Child Health and Development, Tokyo, Japan; Department of Medicine (Garg), Western University, London, Ont.

Michael WalshFrom the Michael G. DeGroote School of Medicine (Kim, Pandey); Department of Health Research Methodology, Evidence, and Impact (Kim, Gupta, Alsagheir, Makhdoum, Walsh, Garg, Guyatt, Whitlock); the Population Health Research Institute (Kim, Belley-Côté, Walsh, Whitlock); Department of Medicine (Belley-Côté, Walsh, Guyatt); Division of Cardiac Surgery (Gupta, Alsagheir, Gao, Whitlock), McMaster University, Hamilton, Ont.; Division of Cardiac Surgery (Makhdoum), University of Toronto, Toronto, Ont.; the Division of Vascular Surgery (McClure), McMaster University, Hamilton, Ont; Faculty of Health Sciences (Newsome), McMaster University, Hamilton, Ont.; Division of Cardiology (Bossard), Heart Center Luzerner Kantonsspital, Luzern, Switzerland; Division of Neonatology (Isayama, Ikuta), National Center for Child Health and Development, Tokyo, Japan; Department of Medicine (Garg), Western University, London, Ont.

Amit X GargFrom the Michael G. DeGroote School of Medicine (Kim, Pandey); Department of Health Research Methodology, Evidence, and Impact (Kim, Gupta, Alsagheir, Makhdoum, Walsh, Garg, Guyatt, Whitlock); the Population Health Research Institute (Kim, Belley-Côté, Walsh, Whitlock); Department of Medicine (Belley-Côté, Walsh, Guyatt); Division of Cardiac Surgery (Gupta, Alsagheir, Gao, Whitlock), McMaster University, Hamilton, Ont.; Division of Cardiac Surgery (Makhdoum), University of Toronto, Toronto, Ont.; the Division of Vascular Surgery (McClure), McMaster University, Hamilton, Ont; Faculty of Health Sciences (Newsome), McMaster University, Hamilton, Ont.; Division of Cardiology (Bossard), Heart Center Luzerner Kantonsspital, Luzern, Switzerland; Division of Neonatology (Isayama, Ikuta), National Center for Child Health and Development, Tokyo, Japan; Department of Medicine (Garg), Western University, London, Ont.

Gordon H GuyattFrom the Michael G. DeGroote School of Medicine (Kim, Pandey); Department of Health Research Methodology, Evidence, and Impact (Kim, Gupta, Alsagheir, Makhdoum, Walsh, Garg, Guyatt, Whitlock); the Population Health Research Institute (Kim, Belley-Côté, Walsh, Whitlock); Department of Medicine (Belley-Côté, Walsh, Guyatt); Division of Cardiac Surgery (Gupta, Alsagheir, Gao, Whitlock), McMaster University, Hamilton, Ont.; Division of Cardiac Surgery (Makhdoum), University of Toronto, Toronto, Ont.; the Division of Vascular Surgery (McClure), McMaster University, Hamilton, Ont; Faculty of Health Sciences (Newsome), McMaster University, Hamilton, Ont.; Division of Cardiology (Bossard), Heart Center Luzerner Kantonsspital, Luzern, Switzerland; Division of Neonatology (Isayama, Ikuta), National Center for Child Health and Development, Tokyo, Japan; Department of Medicine (Garg), Western University, London, Ont.

Richard P WhitlockFrom the Michael G. DeGroote School of Medicine (Kim, Pandey); Department of Health Research Methodology, Evidence, and Impact (Kim, Gupta, Alsagheir, Makhdoum, Walsh, Garg, Guyatt, Whitlock); the Population Health Research Institute (Kim, Belley-Côté, Walsh, Whitlock); Department of Medicine (Belley-Côté, Walsh, Guyatt); Division of Cardiac Surgery (Gupta, Alsagheir, Gao, Whitlock), McMaster University, Hamilton, Ont.; Division of Cardiac Surgery (Makhdoum), University of Toronto, Toronto, Ont.; the Division of Vascular Surgery (McClure), McMaster University, Hamilton, Ont; Faculty of Health Sciences (Newsome), McMaster University, Hamilton, Ont.; Division of Cardiology (Bossard), Heart Center Luzerner Kantonsspital, Luzern, Switzerland; Division of Neonatology (Isayama, Ikuta), National Center for Child Health and Development, Tokyo, Japan; Department of Medicine (Garg), Western University, London, Ont. Richard.Whitlock@phri.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMany patients with end-stage kidney disease (ESKD) have valvular heart disease requiring surgery. The optimal prosthetic valve is not established in this population. We performed a systematic review and meta-analysis to assess outcomes of patients with dialysis-dependent ESKD who received mechanical or bioprosthetic valves.

methodsWe searched Cochrane Central, Medline and Embase from inception to January 2020. We performed screening, full-text assessment, risk of bias and data collection, independently and in duplicate. Data were pooled using a random-effects model.

resultsWe identified 28 observational studies (

conclusionMechanical valves were associated with reduced mortality, but increased rate of bleeding and stroke. Given very low certainty for evidence of mortality and stroke outcomes, patients and clinicians may choose prosthetic valves based on factors such as bleeding risk and valve longevity. STUDY REGISTRATION: PROSPERO no. CRD42017081863.

Indexed as

BioprosthesisHeart Valve DiseasesHeart Valve ProsthesisStrokeHemorrhageHumansRenal Dialysis

Identifiers

PMID35820696

DOI10.1503/cjs.001121

PMCPMC9293484

What OpenQuestion holds

Textmetadata

LicenceCC BY-NC-ND

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.