Evidence map›Paper›PMID 35820682›Full record

ArticleThoracic cancer2022

Comprehensive analysis of the expression and prognosis for RBR E3 ubiquitin ligases in lung adenocarcinoma.

Hao Ding, Yuxin Wang, Yuan Cui, Zhike Chen, Yu Li, Jian Yang, Yang Yang, Tengfei Chen, Dian Xia, Chang Li and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Thoracic cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Hao Ding *Department of Thoracic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, China.
Yuxin Wang *Soochow University Laboratory of Cancer Molecular Genetics, Medical College of Soochow University, Suzhou, China.
Yuan Cui *Department of Thoracic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, China.
Zhike Chen *Department of Thoracic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, China.
Yu LiDepartment of Thoracic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, China.
Jian YangDepartment of Thoracic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, China.
Yang YangKey Lab of Industrial Fermentation Microbiology of the Ministry of Education, School of Biotechnology, Tianjin University of Science and Technology, Tianjin, China.
Tengfei ChenDepartment of Thoracic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, China.ORCID 0000-0001-6579-0320
Dian XiaJiangsu Key Laboratory of Brain Disease and Bioinformation, Xuzhou Medical University, Xuzhou, China.
Chang LiDepartment of Thoracic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, China.
Chun XuDepartment of Thoracic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, China.
Cheng DingDepartment of Thoracic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, China.
Jun ZhaoDepartment of Thoracic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, China.ORCID 0000-0003-3846-8998
Soochow University · CNHeritage Christian University · USTianjin University of Science and Technology · CNXuzhou Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLung adenocarcinoma (LUAD) is the most common subtype of non-small cell lung cancer and has a poor prognosis. RBR E3 ubiquitin ligases are a special class of E3 ubiquitin ligases which contain three zinc-bing domains that catalyze ubiquitin to substrate proteins. The RBR family of E3 ubiquitin ligases has been reported in various human malignancies, but the roles of RBR E3 ubiquitin ligases in LUAD remain unclear.

methodsBy using TCGA and Kaplan-Meier plotter databases, we examined the expression and prognostic value of RBR E3 ubiquitin ligases. cBioPortal was used to analyze genetic mutations. The STRING database was used to build a protein interactive network. GO, KEGG, and GSEA were performed to investigate the potential biological functions of RBR E3 ubiquitin ligases.

resultsThe expression of ARIH2, RNF144B, RNF216, and RNF217 was significantly related to the clinicopathological parameters and prognosis in LUAD patients. GSEA enrichment result showed ARIH2, RNF144B, RNF216, and RNF217 were all associated with NADH dehydrogenase complex assembly. GO functional enrichment analysis revealed that four RBR E3 ubiquitin ligases and their interactors were most correlated with ubiquitin-protein transferase activity. KEGG pathway analysis indicated they were associated with cytosolic DNA-sensing pathway, RIG-I-like receptor signaling pathway and NF-kappa B signaling pathway.

conclusionsOur comprehensive bioinformatic analysis revealed that ARIH2, RNF144B, RNF216, and RNF217 may be new prognostic biomarkers and these findings will help to better understand the distinct roles of RBR E3 ubiquitin ligases in LUAD.

Indexed as

Adenocarcinoma of LungCarcinoma, Non-Small-Cell LungLung NeoplasmsHumansPrognosisUbiquitin-Protein LigasesUbiquitinsARIH2 protein, humanRNF144B protein, humanRNF216 protein, humanUbiquitin-Protein LigasesUbiquitinsbioinformatic analysisbiomarkerslung adenocarcinomaprognosisRBR E3 ubiquitin ligases

Identifiers

PMID35820682
PMCPMC9436683
OpenAlexW4285090853

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.