Evidence map›Paper›PMID 35820561›Full record

ArticleMatrix biology : journal of the International Society for Matrix Biology2022

The phosphorylation of serine

Changchun Dong, Bikash Lamichhane, Hajime Yamazaki, Brent Vasquez, Jingya Wang, Yongxu Zhang, Jian Q Feng, Henry C Margolis, Elia Beniash, Xiaofang Wang

Open access · hybridAbstract read
In one paragraph

Article in Matrix biology : journal of the International Society for Matrix Biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

  1. Reduced Dietary Protein Induces Changes in the Dental Proteome.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2026
    Article
  2. Review
  3. Functions of secretory calcium-binding phosphoproteins in dental mineralization.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2025
    Review
  4. Article
  5. Article
  6. [Frameshift mutation inBeijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2025
    Article
  7. Review
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Changchun DongDepartment of Biomedical Sciences, Texas A&M University School of Dentistry, 3302 Gaston Ave, Dallas, TX 75246, United States.
Bikash LamichhaneDepartment of Biomedical Sciences, Texas A&M University School of Dentistry, 3302 Gaston Ave, Dallas, TX 75246, United States.
Hajime YamazakiDepartment of Oral and Craniofacial Sciences, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, United States.
Brent VasquezDepartment of Oral and Craniofacial Sciences, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, United States.
Jingya WangDepartment of Biomedical Sciences, Texas A&M University School of Dentistry, 3302 Gaston Ave, Dallas, TX 75246, United States.
Yongxu ZhangDepartment of Biomedical Sciences, Texas A&M University School of Dentistry, 3302 Gaston Ave, Dallas, TX 75246, United States.
Jian Q FengDepartment of Biomedical Sciences, Texas A&M University School of Dentistry, 3302 Gaston Ave, Dallas, TX 75246, United States.
Henry C MargolisDepartment of Oral and Craniofacial Sciences, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, United States; Department of Periodontics and Preventive Dentistry, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, United States.
Elia BeniashDepartment of Oral and Craniofacial Sciences, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, United States.
Xiaofang WangDepartment of Biomedical Sciences, Texas A&M University School of Dentistry, 3302 Gaston Ave, Dallas, TX 75246, United States. Electronic address: xfwang@tamu.edu.
Texas A&M University · USUniversity of Pittsburgh · US

Funding

Essential role of amelogenin phosphorylation in tooth enamel formationR01DE029211 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BENIASH, ELIA, MARGOLIS, HENRY C · 2020 to 2024
$2.4M
The Role of FAM20B-catalyzed Proteoglycans in Tooth DevelopmentR01DE026461 · NIDCR · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI WANG, XIAOFANG · 2017 to 2021
$1.8M
The Role of FAM20B-Catalyzed Proteoglycans in Tooth DevelopmentK02DE028345 · NIDCR · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI WANG, XIAOFANG · 2018 to 2022
$746k
NIDCR NIH HHS K02 DE028345NIDCR NIH HHS R01 DE026461NIDCR NIH HHS R01 DE029211
6 · The paper itself

Abstract

Amelogenesis imperfecta (AI) is an inherited developmental enamel defect affecting tooth masticatory function, esthetic appearance, and the well-being of patients. As one of the major enamel matrix proteins (EMPs), enamelin (ENAM) has three serines located in Ser-x-Glu (S-x-E) motifs, which are potential phosphorylation sites for the Golgi casein kinase FAM20C. Defects in FAM20C have similarly been associated with AI. In our previous study of Enam

Indexed as

Amelogenesis ImperfectaDental Enamel ProteinsAmelogenesisAnimalsCalcium-Binding ProteinsExtracellular Matrix ProteinsMiceMice, KnockoutPhosphorylationProteomicsSerineCalcium-Binding ProteinsDental Enamel ProteinsExtracellular Matrix ProteinsFAM20C protein, mouseSerinetuftelinAmelogenesisBiomineralizationEnamelinFAM20CKinasePhosphorylation

Identifiers

PMID35820561
PMCPMC11244640
OpenAlexW4284965627

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.