Evidence map›Paper›PMID 35820368›Full record

ArticleIntervirology2022

Relationship between Human Papillomavirus Prevalence and DNA Damage in Cervical Cancer Population in Gansu Province, China.

Zhong Guo, Tianyuan Zhu, Yunsong Zhou, Tianbin Si, Qiang Wang, Hongmei Qu, Chenjing Wang, Jin Zhao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Intervirology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Zhong GuoMedical College of Northwest Minzu University, Lanzhou, China.
Tianyuan ZhuGansu Provincial Maternity and Child-care Hospital, Lanzhou, China.
Yunsong ZhouMedical College of Northwest Minzu University, Lanzhou, China.
Tianbin SiGansu Provincial Cancer Hospital, Lanzhou, China.
Qiang WangNo. 1 Hospital of Longnan City, Longnan, China.
Hongmei QuMedical College of Northwest Minzu University, Lanzhou, China.
Chenjing WangMedical College of Northwest Minzu University, Lanzhou, China.
Jin ZhaoMedical College of Northwest Minzu University, Lanzhou, China.
Minzu University of China · CNGansu Provincial Hospital · CNGansu Provincial Maternal and Child Health Hospital · CNHainan 301 Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe aim of this study was to assess the possible reason of the high incidence and mortality of cervical cancer in Longnan, China. MATERIALS AND

methods147 and 124 invasive squamous-cell carcinoma (SCC) samples from Longnan and different cities and districts of Gansu province were collected in the present study. All the samples were obtained from patients who underwent biopsies with colposcopy or advanced operations and were evaluated by experienced pathologists. HPV genotypes were examined with a validated HPV subtypes kit. The prevalence of HPV infection in SCC patients of China was analyzed by evidence-based medicine in the published literature. The markers of DNA damage response (DDR) - ATMpSer1981, H2AXp Ser139 (γH2AX), Chk2pThr68, and p53 - were analyzed by immunohistochemistry.

resultsHPV positivity, high-risk and multiple HPV positivity, and HPV58 infection were significantly higher in Longnan. Our results show that the prevalence of HPV infection in SCC patients of Longnan are consistent with the HPV prevalence in China. ATM, γH2AX, and p53 expressions in total and HPV+ samples were also higher in Longnan.

conclusionsHPV-related DDR activation may be one reason for the high incidence and mortality of Longnan cervical cancer.

Indexed as

AlphapapillomavirusCarcinomaPapillomavirus InfectionsUterine Cervical NeoplasmsChinaDNA DamageFemaleGenotypeHumansPapillomaviridaePrevalenceTumor Suppressor Protein p53Tumor Suppressor Protein p53Cervical cancerDNA damage responseHuman papillomaviruses

Identifiers

PMID35820368
PMCPMC9677872
OpenAlexW4285092668

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.