ArticlePloS one2022
Cold sensitivity and its association to functional disability following a major nerve trunk injury in the upper extremity-A national registry-based study.
Article in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 9 citations in OpenAlex.
- Pain medication and nerve injuries in upper or lower limb-a Swedish national registry study.Pain reports · 2026Article
- Article
- Risk of hand and forearm conditions due to vibrating hand-held tools exposure: a retrospective cohort study from Sweden.BMJ open · 2024Article
- Socioeconomic factors and outcome after repair and reconstruction of digital and major nerve trunk injuries in the upper limb.Scientific reports · 2024Article
- Patient reported symptoms and disabilities before and after neuroma surgery: a register-based study.Scientific reports · 2023Article
- Neuromas cause severe residual problems at long-term despite surgery.Scientific reports · 2023Article
- Benign nerve tumours in the upper limb: a registry-based study of symptoms and surgical outcome.Scientific reports · 2023Article
- Experimental study on the repair of peripheral nerve injuriesFrontiers in neurology · 2023Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTo investigate self-reported cold sensitivity and functional disability after a repaired major nerve trunk injury in the upper extremity.
methodsWe identified 735 individuals with a major nerve trunk injury in the upper extremity, surgically treated with direct nerve repair or reconstructed with nerve autografts, in the Swedish national quality registry for hand surgery (HAKIR). Patient-reported symptoms, including cold sensitivity, and perceived disability were collected using two questionnaires (HQ-8 and QuickDASH) preoperatively, and at three and 12 months postoperatively.
resultsWe included 281 individuals, who had responded the questionnaires, where 197 (70%) were men (median age 34 [interquartile range 25-52] years) and 84 (30%) were women (median age 41 [25-55]). Cold sensitivity (scored 0-100) was the most prominent symptom 12 months postoperatively after an injured and repaired/reconstructed median (p<0.001) or ulnar (p<0.001) nerve, while individuals with a radial nerve injury showed milder symptoms. Concomitant injuries did not affect cold sensitivity scores. Individuals with ulnar nerve injuries scored higher in stiffness (p = 0.019), weakness (p<0.001) and ability to perform daily activities (p = 0.003) at 12 months postoperatively than median nerve injuries. Individuals with a median, ulnar or radial nerve injury with severe (>70) cold sensitivity had 25, 37 and 30 points higher QuickDASH scores, respectively (p<0.001), at 12 months postoperatively than individuals with mild (<30) cold sensitivity. There were no differences in QuickDASH score or cold sensitivity score at 12 months postoperatively between direct nerve repair or nerve reconstruction with nerve autografts. Neither age, nor sex, affected QuickDASH score at 12 months postoperatively.
conclusionCold sensitivity after surgery for a major nerve trunk injury in the upper extremity can be substantial with impaired ability to perform daily activities, where an ulnar nerve injury may have a worse outcome.
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