Evidence map›Paper›PMID 35819919›Full record

Trial reportBritish journal of haematology2022

Liposomal doxorubicin supercharge-containing front-line treatment in patients with advanced-stage diffuse large B-cell lymphoma or classical Hodgkin lymphoma: Preliminary results of a single-centre phase II study.

Marco Picardi, Claudia Giordano, Novella Pugliese, Maria Esposito, Melania Fatigati, Francesco Muriano, Maria G Rascato, Roberta Della Pepa, Alessandro D'Ambrosio, Elena Vigliar and 11 more

Open access · hybridAbstract readClinical Trial, Phase II
In one paragraph

Trial report in British journal of haematology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 2 pooled it
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 1 institution in 1 country.

Marco PicardiDepartment of Clinical Medicine and Surgery, Federico II University Medical School, Naples, Italy.ORCID 0000-0001-8508-2524
Claudia GiordanoDepartment of Clinical Medicine and Surgery, Federico II University Medical School, Naples, Italy.ORCID 0000-0003-3943-4263
Novella PuglieseDepartment of Clinical Medicine and Surgery, Federico II University Medical School, Naples, Italy.ORCID 0000-0002-2714-5109
Maria EspositoDepartment of Clinical Medicine and Surgery, Federico II University Medical School, Naples, Italy.
Melania FatigatiDepartment of Clinical Medicine and Surgery, Federico II University Medical School, Naples, Italy.
Francesco MurianoDepartment of Clinical Medicine and Surgery, Federico II University Medical School, Naples, Italy.
Maria G RascatoDepartment of Clinical Medicine and Surgery, Federico II University Medical School, Naples, Italy.
Roberta Della PepaDepartment of Clinical Medicine and Surgery, Federico II University Medical School, Naples, Italy.ORCID 0000-0001-5641-231X
Alessandro D'AmbrosioDepartment of Clinical Medicine and Surgery, Federico II University Medical School, Naples, Italy.
Elena VigliarDepartment of Public Health, Federico II University Medical School, Naples, Italy.
Giancarlo TronconeDepartment of Public Health, Federico II University Medical School, Naples, Italy.
Daniela RussoDepartment of Advanced Biomedical Sciences, Federico II University Medical School, Naples, Italy.
Massimo MascoloDepartment of Advanced Biomedical Sciences, Federico II University Medical School, Naples, Italy.
Giovanni EspositoDepartment of Advanced Biomedical Sciences, Federico II University Medical School, Naples, Italy.
Mariella PrastaroDepartment of Advanced Biomedical Sciences, Federico II University Medical School, Naples, Italy.
Roberta EspositoDepartment of Clinical Medicine and Surgery, Federico II University Medical School, Naples, Italy.
Carlo G TocchettiDepartments of Translational Medical Sciences, Federico II University Medical School, Naples, Italy.
Rosa FontiDepartment of Advanced Biomedical Sciences, Federico II University Medical School, Naples, Italy.
Ciro MainolfiDepartment of Advanced Biomedical Sciences, Federico II University Medical School, Naples, Italy.
Silvana Del VecchioDepartment of Advanced Biomedical Sciences, Federico II University Medical School, Naples, Italy.
Fabrizio PaneDepartment of Clinical Medicine and Surgery, Federico II University Medical School, Naples, Italy.ORCID 0000-0003-2563-4125
Federico II University Hospital · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We evaluated the impact of liposomal doxorubicin (NPLD) supercharge-containing therapy on interim fluorodeoxyglucose positron emission tomography (interim-FDG-PET) responses in high-risk diffuse large B-cell lymphoma (DLBCL) or classical Hodgkin lymphoma (c-HL). In this phase II study (2016-2021), 81 adult patients with advanced-stage DLBCL (n = 53) and c-HL (n = 28) received front-line treatment with R-COMP-dose-intensified (DI) and MBVD-DI. R-COMP-DI consisted of 70 mg/m

Indexed as

Hodgkin DiseaseLymphoma, Large B-Cell, DiffuseAdultAntineoplastic Combined Chemotherapy ProtocolsCyclophosphamideDoxorubicinEtoposideFluorodeoxyglucose F18HumansNeoplasm StagingPolyethylene GlycolsPrednisoneRituximabVincristineCyclophosphamideDoxorubicinEtoposideFluorodeoxyglucose F18liposomal doxorubicinPolyethylene GlycolsPrednisoneRituximabVincristinec-HLDLBCLhigh-dose non-pegylated liposomal doxorubicinR-COMP and MBVD

Identifiers

PMID35819919
PMCPMC9541306
OpenAlexW4285077460

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.