Evidence map›Paper›PMID 35819818›Full record

ArticleAngewandte Chemie (International ed. in English)2022

Methyl Substitution Destabilizes Alkyl Radicals.

Eva Blokker, Willem-Jan van Zeist, Xiaobo Sun, Jordi Poater, J Martijn van der Schuur, Trevor A Hamlin, F Matthias Bickelhaupt

Abstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Radical Stability Paradox: Substituent Effects versus Heats of Formation.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026
    Article
  3. Article
  4. Article
  5. Concise Synthesis of Cyctetryptomycin A and B Enabled by Zr-Catalyzed Dimerization.Angewandte Chemie (International ed. in English) · 2025
    Article
  6. Article
  7. The Mechanism of Inhibition of Pyruvate Formate Lyase by Methacrylate.Journal of the American Chemical Society · 2023
    Article
  8. Methyl Substitution Destabilizes Alkyl Radicals.Angewandte Chemie (International ed. in English) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Eva BlokkerDepartment of Theoretical Chemistry, Amsterdam Institute of Molecular and Life Sciences (AIMMS), Amsterdam Center for Multiscale Modeling (ACMM), Vrije Universiteit Amsterdam, De Boelelaan 1083, 1081 HV, Amsterdam, The Netherlands.ORCID 0000-0003-3687-3367
Willem-Jan van ZeistDepartment of Theoretical Chemistry, Amsterdam Institute of Molecular and Life Sciences (AIMMS), Amsterdam Center for Multiscale Modeling (ACMM), Vrije Universiteit Amsterdam, De Boelelaan 1083, 1081 HV, Amsterdam, The Netherlands.
Xiaobo SunDepartment of Theoretical Chemistry, Amsterdam Institute of Molecular and Life Sciences (AIMMS), Amsterdam Center for Multiscale Modeling (ACMM), Vrije Universiteit Amsterdam, De Boelelaan 1083, 1081 HV, Amsterdam, The Netherlands.ORCID 0000-0003-2483-8476
Jordi PoaterDepartament de Química Inorgànica i Orgànica & IQTCUB, Universitat de Barcelona, Martí i Franquès 1-11, 08028, Barcelona, Spain.ORCID 0000-0002-0814-5074
J Martijn van der SchuurPolymer Specialties, Nouryon, Zutphenseweg 10, 7418 AJ, Deventer, The Netherlands.ORCID 0000-0002-0292-2661
Trevor A HamlinDepartment of Theoretical Chemistry, Amsterdam Institute of Molecular and Life Sciences (AIMMS), Amsterdam Center for Multiscale Modeling (ACMM), Vrije Universiteit Amsterdam, De Boelelaan 1083, 1081 HV, Amsterdam, The Netherlands.ORCID 0000-0002-5128-1004
F Matthias BickelhauptDepartment of Theoretical Chemistry, Amsterdam Institute of Molecular and Life Sciences (AIMMS), Amsterdam Center for Multiscale Modeling (ACMM), Vrije Universiteit Amsterdam, De Boelelaan 1083, 1081 HV, Amsterdam, The Netherlands.ORCID 0000-0003-4655-7747

Funding

ARC CBBC 2018.019.BMINECO PID2019-106830GB-I00 and MDM-2017-0767Nederlandse Organisatie voor Wetenschappelijk Onderzoek NWO
6 · The paper itself

Abstract

We have quantum chemically investigated how methyl substituents affect the stability of alkyl radicals Me

Indexed as

Bond Dissociation EnergyBonding TheoryDensity Functional CalculationsRadicalsSubstituent Effects

Identifiers

PMID35819818
PMCPMC9545886

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.