Evidence map›Paper›PMID 35819715›Full record

ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2023

To what extent does prior antimicrobial therapy affect the diagnostic performance of radiolabeled leukocyte scintigraphy in infective endocarditis?

Katarzyna Holcman, Paweł Rubiś, Bogdan Ćmiel, Andrzej Ząbek, Krzysztof Boczar, Wojciech Szot, Zuzanna Kalarus, Katarzyna Graczyk, Maksymilian Hanarz, Barbara Małecka and 2 more

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In one paragraph

Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Diagnostic accuracy of radiolabelled-WBC scintigraphy in patients with antibiotic therapy.European journal of nuclear medicine and molecular imaging · 2026
    Article
  3. Review
  4. Review
  5. Novel Diagnostic Methods for Infective Endocarditis.International journal of molecular sciences · 2024
    Review
  6. First-in-human infection imaging withFrontiers in nuclear medicine · 2024
    Article
  7. Review
  8. Review
  9. Negative influence of antimicrobial therapy on radiolabeled white blood cells scintigraphy performance in infective endocarditis: myth or fact?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Katarzyna HolcmanDepartment of Cardiac and Vascular Diseases, Jagiellonian University Medical College, John Paul II Hospital, Pradnicka 80, 31-202, Krakow, Poland. katarzyna.holcman@gmail.com.ORCID 0000-0002-6895-4076
Paweł RubiśDepartment of Cardiac and Vascular Diseases, Jagiellonian University Medical College, John Paul II Hospital, Pradnicka 80, 31-202, Krakow, Poland.
Bogdan ĆmielFaculty of Applied Mathematics, AGH University of Science and Technology, Krakow, Poland.
Andrzej ZąbekDepartment of Electrocardiology, Jagiellonian University Medical College, John Paul II Hospital, Krakow, Poland.
Krzysztof BoczarDepartment of Electrocardiology, Jagiellonian University Medical College, John Paul II Hospital, Krakow, Poland.
Wojciech SzotDepartment of Nuclear Medicine, John Paul II Hospital, Krakow, Poland.
Zuzanna KalarusDepartment of Cardiac and Vascular Diseases, Jagiellonian University Medical College, John Paul II Hospital, Pradnicka 80, 31-202, Krakow, Poland.
Katarzyna GraczykDepartment of Cardiac and Vascular Diseases, Jagiellonian University Medical College, John Paul II Hospital, Pradnicka 80, 31-202, Krakow, Poland.
Maksymilian HanarzDepartment of Cardiac and Vascular Diseases, Jagiellonian University Medical College, John Paul II Hospital, Pradnicka 80, 31-202, Krakow, Poland.
Barbara MałeckaDepartment of Electrocardiology, Jagiellonian University Medical College, John Paul II Hospital, Krakow, Poland.
Piotr PodolecDepartment of Cardiac and Vascular Diseases, Jagiellonian University Medical College, John Paul II Hospital, Pradnicka 80, 31-202, Krakow, Poland.
Magdalena KostkiewiczDepartment of Cardiac and Vascular Diseases, Jagiellonian University Medical College, John Paul II Hospital, Pradnicka 80, 31-202, Krakow, Poland.
Jagiellonian University · PLAGH University of Krakow · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsThis prospective, single-center study sought to assess to what extent there is interference between the hybrid technique of single-photon emission tomography-computed tomography with technetium99m-hexamethylpropyleneamine oxime-labeled leukocytes (99mTc-HMPAO-SPECT/CT) and antimicrobial therapy in patients with infective endocarditis (IE). METHODS AND

resultsDuring the years 2015-2019, we enrolled 205 consecutive adults with suspected IE, all underwent 99mTc-HMPAO-SPECT/CT. The study population was divided into those who had received antimicrobial therapy up to 30 days prior to 99mTc-HMPAO-SPECT/CT (group 1, n = 96) and those who had not (group 2, n = 109). Patients were prospectively observed for 12 ± 10 months. Group 1 presented higher positive predictive values (91.89% vs. 60.00%, = 0.001), and decreased negative predictive values (77.97% vs. 90.54%, P = 0.04). Patients treated with antimicrobial therapy displayed false-negative 99mTc-HMPAO-SPECT/CT results more often [odds ratio (OR), 4.63; 95% confidence interval (CI), 1.41-15.23, P = .01], particularly when intravenous (OR 5.37; 95% CI 1.73-16.62, P = .004), definite (OR 9.43; 95% CI 2.65-33.51, P = .001), and combination antibiotic regimens (OR 8.1; 95% CI 2.57-25.64, P = .001) had been administered.

conclusionPrior antibiotic therapy affects 99mTc-HMPAO-SPECT/CT diagnostic properties. Patients treated with antimicrobial therapy display false-negative 99mTc-HMPAO-SPECT/CT results more often, especially if intravenous, definite, or combination regimens are administered.

Indexed as

Anti-Infective AgentsEndocarditisEndocarditis, BacterialAdultHumansLeukocytesProspective StudiesTechnetium Tc 99m ExametazimeTomography, Emission-Computed, Single-PhotonAnti-Infective AgentsTechnetium Tc 99m Exametazimehybrid imagingInfectionSPECT

Identifiers

PMID35819715
OpenAlexW4285037928

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.