Evidence map›Paper›PMID 35819709›Full record

ArticleMetabolic brain disease2022

CDGSH iron sulfur domain 2 mitigates apoptosis, oxidative stress and inflammatory response caused by oxygen-glucose deprivation/reoxygenation in HT22 hippocampal neurons by Akt-Nrf2-activated pathway.

Xiaoyan Ren, Jiangang Yu, Lili Guo, Zaili Zhang

Abstract read
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In one paragraph

Article in Metabolic brain disease, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Xiaoyan RenAnesthesiology Department, The First Affiliated Hospital of China Medical University, No.155 Nanjing North Street, Shenyang, 110001, Liaoning Province, China.
Jiangang YuAnesthesiology Department, The First Affiliated Hospital of China Medical University, No.155 Nanjing North Street, Shenyang, 110001, Liaoning Province, China.
Lili GuoAnesthesiology Department, The First Affiliated Hospital of China Medical University, No.155 Nanjing North Street, Shenyang, 110001, Liaoning Province, China.
Zaili ZhangAnesthesiology Department, The First Affiliated Hospital of China Medical University, No.155 Nanjing North Street, Shenyang, 110001, Liaoning Province, China. zhangzaili333@163.com.ORCID http://orcid.org/0000-0002-5564-0991
First Hospital of China Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

CDGSH iron sulfur domain 2 (Cisd2) is known as a key determinant factor in maintaining cellular homeostasis. However, whether Cisd2 contributes to the mediation of neuronal injury during ischemic stroke has not been well stressed. This work focuses on investigating the role of Cisd2 in regulating neuronal injury caused by oxygen-glucose deprivation/reoxygenation (OGD/R). The dramatic down-regulation of Cisd2 was observed in hippocampal neurons suffering from OGD/R injury. In Cisd2-overexpressed neurons, OGD/R-induced neuronal apoptosis, oxidative stress and inflammation were prominently mitigated. Further investigation uncovered that the forced expression of Cisd2 reinforced the activation of nuclear factor erythroid 2-related factor 2 (Nrf2) pathway in OGD/R-exposed neurons. Moreover, the overexpression of Cisd2 enhanced Akt activation, and the restraint of Akt abolished Cisd2-induced Nrf2 activation. Importantly, restraint of Nrf2 reversed Cisd2-conferred neuroprotective effects in OGD/R-exposed neurons. Taken together, our findings indicate that Cisd2 is able to protect neurons from OGD/R-induced injuries by strengthening Nrf2 activation via Akt. Our work identifies Cisd2 as a potential determinant factor for neuronal injury during cerebral ischemia/reperfusion injury.

Indexed as

Neuroprotective AgentsReperfusion InjuryApoptosisGlucoseHippocampusHumansIronMembrane ProteinsNeuronsNF-E2-Related Factor 2Oxidative StressOxygenProto-Oncogene Proteins c-aktSignal TransductionSulfurCISD2 protein, humanGlucoseIronMembrane ProteinsNeuroprotective AgentsNF-E2-Related Factor 2OxygenProto-Oncogene Proteins c-aktSulfurAktCisd2NeuronNrf2Oxygen–glucose deprivation/reoxygenation

Identifiers

PMID35819709
OpenAlexW4285076874

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.