Evidence map›Paper›PMID 35819695›Full record

ReviewImmunologic research2022

Cytokine storm and targeted therapy in hemophagocytic lymphohistiocytosis.

Han-Qi Zhang, Si-Wei Yang, Yi-Cheng Fu, Ming-Cong Chen, Cheng-Hao Yang, Ming-Hua Yang, Xiao-Dan Liu, Qing-Nan He, Hua Jiang, Ming-Yi Zhao

Abstract readReview
PubMed Publisher
In one paragraph

Review in Immunologic research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  16. The anti-inflammatory effect of metformin: The molecular targets.Genes to cells : devoted to molecular & cellular mechanisms · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Han-Qi Zhang *Department of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha, 410013, Hunan, China.
Si-Wei Yang *Department of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha, 410013, Hunan, China.
Yi-Cheng FuDepartment of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha, 410013, Hunan, China.
Ming-Cong ChenDepartment of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha, 410013, Hunan, China.
Cheng-Hao YangDepartment of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha, 410013, Hunan, China.
Ming-Hua YangDepartment of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha, 410013, Hunan, China.
Xiao-Dan LiuDepartment of Hematology/Oncology, Guangzhou Women and Children's Medical Center, Guangzhou, 510623, Guangdong, China.
Qing-Nan HeDepartment of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha, 410013, Hunan, China. heqn2629@csu.edu.cn.
Hua JiangDepartment of Hematology/Oncology, Guangzhou Women and Children's Medical Center, Guangzhou, 510623, Guangdong, China. jiang_hua18@sina.cn.
Ming-Yi ZhaoDepartment of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha, 410013, Hunan, China. zhao_mingyi@csu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening systemic hyperinflammatory syndrome. The central pathogenesis is an explosive cytokine storm characterized by a significant increase in proinflammatory cytokines, including IL-1β, IL-6, IL-18, IFN-γ, and TNF-α. Meanwhile, negative regulatory factors, such as IL-10 and TGF-β, are also related to the production of HLH. Exploring the specific mechanism of cytokine storms could provide ideas regarding targeted therapy, which could be helpful for early treatment to reduce the mortality of HLH. Although some research has focused on the advantages of targeted therapies, there is still a lack of a comprehensive discourse. This article attempts to summarize the mechanisms of action of various cytokines and provide a therapeutic overview of the current targeted therapies for HLH.

Indexed as

Lymphohistiocytosis, HemophagocyticCytokine Release SyndromeCytokinesHumansInterleukin-10Interleukin-18Interleukin-6Transforming Growth Factor betaTumor Necrosis Factor-alphaCytokinesInterleukin-10Interleukin-18Interleukin-6Transforming Growth Factor betaTumor Necrosis Factor-alphaCytokine inhibitorCytokine stormHemophagocytic lymphohistiocytosisIFN-γTargeted therapy

Identifiers

PMID35819695

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.