Evidence map›Paper›PMID 35819325›Full record

ArticleRadiology2022

Quantitative CT Evaluation of Small Pulmonary Vessels Has Functional and Prognostic Value in Pulmonary Hypertension.

Yousef Shahin, Samer Alabed, Dheyaa Alkhanfar, Juerg Tschirren, Alex M K Rothman, Robin Condliffe, James M Wild, David G Kiely, Andrew J Swift

Open access · hybridAbstract read
In one paragraph

Article in Radiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Yousef ShahinFrom the Department of Infection, Immunity and Cardiovascular Disease (Y.S., S.A., D.A., A.M.K.R., J.M.W., D.G.K., A.J.S.) and INSIGNEO, Institute for in silico Medicine (D.G.K., A.J.S.), University of Sheffield, Glossop Rd, Sheffield S10 2JF, England; Department of Clinical Radiology, Sheffield Teaching Hospitals, Sheffield, England (Y.S., S.A., A.J.S.); VIDA Diagnostics, Coralville, Iowa (J.T.); and Sheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield, England (R.C., D.G.K.).ORCID 0000-0001-7425-7798
Samer AlabedFrom the Department of Infection, Immunity and Cardiovascular Disease (Y.S., S.A., D.A., A.M.K.R., J.M.W., D.G.K., A.J.S.) and INSIGNEO, Institute for in silico Medicine (D.G.K., A.J.S.), University of Sheffield, Glossop Rd, Sheffield S10 2JF, England; Department of Clinical Radiology, Sheffield Teaching Hospitals, Sheffield, England (Y.S., S.A., A.J.S.); VIDA Diagnostics, Coralville, Iowa (J.T.); and Sheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield, England (R.C., D.G.K.).ORCID 0000-0002-9960-7587
Dheyaa AlkhanfarFrom the Department of Infection, Immunity and Cardiovascular Disease (Y.S., S.A., D.A., A.M.K.R., J.M.W., D.G.K., A.J.S.) and INSIGNEO, Institute for in silico Medicine (D.G.K., A.J.S.), University of Sheffield, Glossop Rd, Sheffield S10 2JF, England; Department of Clinical Radiology, Sheffield Teaching Hospitals, Sheffield, England (Y.S., S.A., A.J.S.); VIDA Diagnostics, Coralville, Iowa (J.T.); and Sheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield, England (R.C., D.G.K.).
Juerg TschirrenFrom the Department of Infection, Immunity and Cardiovascular Disease (Y.S., S.A., D.A., A.M.K.R., J.M.W., D.G.K., A.J.S.) and INSIGNEO, Institute for in silico Medicine (D.G.K., A.J.S.), University of Sheffield, Glossop Rd, Sheffield S10 2JF, England; Department of Clinical Radiology, Sheffield Teaching Hospitals, Sheffield, England (Y.S., S.A., A.J.S.); VIDA Diagnostics, Coralville, Iowa (J.T.); and Sheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield, England (R.C., D.G.K.).ORCID 0000-0001-9108-6353
Alex M K RothmanFrom the Department of Infection, Immunity and Cardiovascular Disease (Y.S., S.A., D.A., A.M.K.R., J.M.W., D.G.K., A.J.S.) and INSIGNEO, Institute for in silico Medicine (D.G.K., A.J.S.), University of Sheffield, Glossop Rd, Sheffield S10 2JF, England; Department of Clinical Radiology, Sheffield Teaching Hospitals, Sheffield, England (Y.S., S.A., A.J.S.); VIDA Diagnostics, Coralville, Iowa (J.T.); and Sheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield, England (R.C., D.G.K.).
Robin CondliffeFrom the Department of Infection, Immunity and Cardiovascular Disease (Y.S., S.A., D.A., A.M.K.R., J.M.W., D.G.K., A.J.S.) and INSIGNEO, Institute for in silico Medicine (D.G.K., A.J.S.), University of Sheffield, Glossop Rd, Sheffield S10 2JF, England; Department of Clinical Radiology, Sheffield Teaching Hospitals, Sheffield, England (Y.S., S.A., A.J.S.); VIDA Diagnostics, Coralville, Iowa (J.T.); and Sheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield, England (R.C., D.G.K.).
James M WildFrom the Department of Infection, Immunity and Cardiovascular Disease (Y.S., S.A., D.A., A.M.K.R., J.M.W., D.G.K., A.J.S.) and INSIGNEO, Institute for in silico Medicine (D.G.K., A.J.S.), University of Sheffield, Glossop Rd, Sheffield S10 2JF, England; Department of Clinical Radiology, Sheffield Teaching Hospitals, Sheffield, England (Y.S., S.A., A.J.S.); VIDA Diagnostics, Coralville, Iowa (J.T.); and Sheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield, England (R.C., D.G.K.).ORCID 0000-0002-7246-8660
David G KielyFrom the Department of Infection, Immunity and Cardiovascular Disease (Y.S., S.A., D.A., A.M.K.R., J.M.W., D.G.K., A.J.S.) and INSIGNEO, Institute for in silico Medicine (D.G.K., A.J.S.), University of Sheffield, Glossop Rd, Sheffield S10 2JF, England; Department of Clinical Radiology, Sheffield Teaching Hospitals, Sheffield, England (Y.S., S.A., A.J.S.); VIDA Diagnostics, Coralville, Iowa (J.T.); and Sheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield, England (R.C., D.G.K.).ORCID 0000-0003-0184-6502
Andrew J SwiftFrom the Department of Infection, Immunity and Cardiovascular Disease (Y.S., S.A., D.A., A.M.K.R., J.M.W., D.G.K., A.J.S.) and INSIGNEO, Institute for in silico Medicine (D.G.K., A.J.S.), University of Sheffield, Glossop Rd, Sheffield S10 2JF, England; Department of Clinical Radiology, Sheffield Teaching Hospitals, Sheffield, England (Y.S., S.A., A.J.S.); VIDA Diagnostics, Coralville, Iowa (J.T.); and Sheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield, England (R.C., D.G.K.).ORCID 0000-0002-8772-409X
Sheffield Teaching Hospitals NHS Foundation Trust · GBUniversity of Sheffield · GBRoyal Hallamshire Hospital · GBVida Diagnostics (United States) · US

Funding

British Heart Foundation SP/14/6/31350Medical Research Council MR/M008894/1Wellcome Trust 205188/Z/16/Z
6 · The paper itself

Abstract

Background The in vivo relationship between peel pulmonary vessels, small pulmonary vessels, and pulmonary hypertension (PH) is not fully understood. Purpose To quantitatively assess peel pulmonary vessel volumes (PPVVs) and small pulmonary vessel volumes (SPVVs) as estimated from CT pulmonary angiography (CTPA) in different subtypes of PH compared with controls, their relationship to pulmonary function and right heart catheter metrics, and their prognostic value. Materials and Methods In this retrospective single-center study performed from January 2008 to February 2018, quantitative CTPA analysis of total SPVV (TSPVV) (0.4- to 2-mm vessel diameter) and PPVV (within 15, 30, and 45 mm from the lung surface) was performed. Results A total of 1823 patients (mean age, 69 years ± 13 [SD]; 1192 women [65%]) were retrospectively analyzed; 1593 patients with PH (mean pulmonary arterial pressure [mPAP], 43 mmHg ± 13 [SD]) were compared with 230 patient controls (mPAP, 19 mm Hg ± 3). The mean vessel volumes in pulmonary peels at 15-, 30-, and 45-mm depths were higher in pulmonary arterial hypertension (PAH) and PH secondary to lung disease compared with chronic thromboembolic PH (45-mm peel, mean difference: 6.4 mL [95% CI: 1, 11] [

Indexed as

Heart DiseasesHypertension, PulmonaryPulmonary Arterial HypertensionAgedComputed Tomography AngiographyFemaleHumansLungPrognosisPulmonary ArteryRetrospective Studies

Identifiers

PMID35819325
PMCPMC9619204
OpenAlexW4285029194

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.