Evidence map›Paper›PMID 35819184›Full record

ReviewMagnetic resonance in medicine2022

Velocity-selective arterial spin labeling perfusion MRI: A review of the state of the art and recommendations for clinical implementation.

Qin Qin, David C Alsop, Divya S Bolar, Luis Hernandez-Garcia, James Meakin, Dapeng Liu, Krishna S Nayak, Sophie Schmid, Matthias J P van Osch, Eric C Wong and 6 more

Erratum issuedOpen access · hybridAbstract readReview
In one paragraph

Review in Magnetic resonance in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
8.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 64 citations in OpenAlex.

  1. Article
  2. Article
  3. Ultrafast Blood TMagnetic resonance in medicine · 2026
    Article
  4. Article
  5. Article
  6. Characterizing pre- and post-operative cerebral blood flow and transit time in pediatric moyamoya patients using multi-delay ASL and DSC MRI.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2025
    Article
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  9. Review
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  11. Review
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  15. Article
  16. Article
  17. Review
  18. The Consortium for Clarity in ADRD Research Through Imaging (CLARiTI).Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 10 institutions in 2 countries.

Qin QinThe Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0002-6432-2944
David C AlsopDepartment of Radiology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA.
Divya S BolarCenter for Functional Magnetic Resonance Imaging, Department of Radiology, University of California, San Diego La Jolla, California, USA.
Luis Hernandez-GarciaFMRI Laboratory, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0003-3002-0304
James MeakinDepartment of Radiology, Nuclear Medicine and Anatomy, Radboud University Medical Center, Nijmegen, The Netherlands.
Dapeng LiuThe Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0002-4432-3202
Krishna S NayakMagnetic Resonance Engineering Laboratory, Ming Hsieh Department of Electrical Engineering, University of Southern California, Los Angeles, California, USA.ORCID 0000-0001-5735-3550
Sophie SchmidC.J. Gorter Center for high field MRI, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands.ORCID 0000-0003-0750-7798
Matthias J P van OschC.J. Gorter Center for high field MRI, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands.ORCID 0000-0001-7034-8959
Eric C WongCenter for Functional Magnetic Resonance Imaging, Department of Radiology, University of California, San Diego La Jolla, California, USA.
Joseph G WoodsCenter for Functional Magnetic Resonance Imaging, Department of Radiology, University of California, San Diego La Jolla, California, USA.ORCID 0000-0002-0329-824X
Greg ZaharchukDepartment of Radiology, Stanford University, Stanford, California, USA.
Moss Y ZhaoDepartment of Radiology, Stanford University, Stanford, California, USA.ORCID 0000-0002-0210-7739
Zungho ZunDepartment of Radiology, Weill Cornell Medicine, New York, New York, USA.ORCID 0000-0002-7297-3990
Jia GuoDepartment of Bioengineering, University of California Riverside, Riverside, California, USA.ORCID 0000-0003-3371-5857
ISMRMPerfusion Study Group
University of California San Diego · USJohns Hopkins University · USLeiden University Medical Center · NLStanford University · USBeth Israel Deaconess Medical Center · USCornell University · USRadboud University Nijmegen · NLUniversity of California, Riverside · USUniversity of Michigan · USUniversity of Southern California · US

Funding

Clinical and Translational Science AwardUL1TR001873 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI REILLY, MUREDACH P · 2016 to 2025
$99.0M
Disparities in COVID Disease Severity and Outcomes in New York CityUL1TR002384 · NCATS · WEILL MEDICAL COLL OF CORNELL UNIV · PI JULIANNE L IMPERATO-MCGINLEY · 2017 to 2026
$86.2M
TRD 4: Platforms for multi-modal and multi-scale imaging dataP41EB031771 · NIBIB · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI Hanzhang Lu, Peter CM Van Zijl · 2021 to 2026
$9.9M
Mechanisms of Brain Dysmorphology in MN1 C-Terminal Truncation Syndrome, a Novel Intellectual Developmental Disability Disorder P50HD103524 · NICHD · UNIVERSITY OF WASHINGTON · PI Sandra E Juul · 2020 to 2026
$9.9M
Cerebrovascular Reserve Imaging with Simultaneous PET/MRI Using Arterial Spin Labeling and Deep LearningR01EB025220 · NIBIB · STANFORD UNIVERSITY · PI ZAHARCHUK, GREGORY GEORGE · 2018 to 2021
$2.8M
Assessment of placental perfusion and oxygenation using novel MRI approaches.R01HD100012 · NICHD · WEILL MEDICAL COLL OF CORNELL UNIV · PI ZUN, ZUNGHO · 2019 to 2022
$2.4M
Non-Contrast-Enhanced Velocity-Selective MR Angiography at 3T for Cerebrovascular DiseasesR01HL138182 · NHLBI · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI QIN, QIN · 2018 to 2022
$2.0M
Quantitative MR Imaging of Vascular Factors in Parkinsons DiseaseR01NS112233 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HERNANDEZ-GARCIA, LUIS · 2020 to 2024
$1.8M
Novel Myocardial Perfusion Stress Test using Arterial Spin LabelingR01HL130494 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI NAYAK, KRISHNA S · 2016 to 2019
$1.7M
Velocity-Selective Arterial Spin Labeling based Perfusion Mapping for Cerebrovascular DiseasesR01HL144751 · NHLBI · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI QIN, QIN · 2019 to 2022
$1.7M
Ultra-fast cerebral blood flow imaging for quantifying brain dynamicsR01EB033210 · NIBIB · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI GUO, JIA · 2022 to 2022
$623k
NCATS NIH HHS UL1 TR001873NCATS NIH HHS UL1 TR002384NHLBI NIH HHS R01 HL130494NHLBI NIH HHS R01 HL138182NHLBI NIH HHS R01 HL144751NIBIB NIH HHS P41 EB031771NIBIB NIH HHS R01 EB025220NIBIB NIH HHS R01 EB033210NICHD NIH HHS P50 HD103524NICHD NIH HHS R01 HD100012NINDS NIH HHS R01 NS112233
6 · The paper itself

Abstract

This review article provides an overview of the current status of velocity-selective arterial spin labeling (VSASL) perfusion MRI and is part of a wider effort arising from the International Society for Magnetic Resonance in Medicine (ISMRM) Perfusion Study Group. Since publication of the 2015 consensus paper on arterial spin labeling (ASL) for cerebral perfusion imaging, important advancements have been made in the field. The ASL community has, therefore, decided to provide an extended perspective on various aspects of technical development and application. Because VSASL has the potential to become a principal ASL method because of its unique advantages over traditional approaches, an in-depth discussion was warranted. VSASL labels blood based on its velocity and creates a magnetic bolus immediately proximal to the microvasculature within the imaging volume. VSASL is, therefore, insensitive to transit delay effects, in contrast to spatially selective pulsed and (pseudo-) continuous ASL approaches. Recent technical developments have improved the robustness and the labeling efficiency of VSASL, making it a potentially more favorable ASL approach in a wide range of applications where transit delay effects are of concern. In this review article, we (1) describe the concepts and theoretical basis of VSASL; (2) describe different variants of VSASL and their implementation; (3) provide recommended parameters and practices for clinical adoption; (4) describe challenges in developing and implementing VSASL; and (5) describe its current applications. As VSASL continues to undergo rapid development, the focus of this review is to summarize the fundamental concepts of VSASL, describe existing VSASL techniques and applications, and provide recommendations to help the clinical community adopt VSASL.

Indexed as

Cerebrovascular CirculationMagnetic Resonance AngiographyMagnetic Resonance ImagingPerfusionSpin LabelsSpin Labelsarterial spin labelingarterial transit delaycerebral blood flowperfusionvelocity selective arterial spin labelingvelocity selectivity

Identifiers

PMID35819184
PMCPMC9543181
OpenAlexW4285077422

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.