Evidence map›Paper›PMID 35819158›Full record

ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2022

Feeding mode influences dynamic gut microbiota signatures and affects susceptibility to anti-CD3 mAb-induced intestinal injury in neonatal mice.

Saravanan Subramanian, Hua Geng, Chao Du, Pauline M Chou, Heng-Fu Bu, Xiao Wang, Suchitra Swaminathan, Stephanie C Tan, Jason M Ridlon, Isabelle G De Plaen and 1 more

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Gastrointestinal and liver physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

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  8. State-of-the-art review and update ofFrontiers in pediatrics · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Saravanan SubramanianDivision of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Center for Intestinal and Liver Inflammation Research, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois.
Hua GengDivision of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Center for Intestinal and Liver Inflammation Research, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois.
Chao DuDivision of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Center for Intestinal and Liver Inflammation Research, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois.
Pauline M ChouDepartment of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
Heng-Fu BuDivision of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Center for Intestinal and Liver Inflammation Research, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois.
Xiao WangDivision of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Center for Intestinal and Liver Inflammation Research, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois.
Suchitra SwaminathanDivision of Rheumatology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
Stephanie C TanDivision of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Center for Intestinal and Liver Inflammation Research, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois.
Jason M RidlonDepartment of Animal Sciences, University of Illinois Urbana-Champaign, Urbana, Illinois.
Isabelle G De PlaenDepartment of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
Xiao-Di TanDivision of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Center for Intestinal and Liver Inflammation Research, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois.
Northwestern University · USLurie Children's Hospital · USJesse Brown VA Medical Center · USUniversity of Illinois Urbana-Champaign · US

Funding

Strengthening Stakeholder Engagement in Human Research Protections.UL1TR002003 · NCATS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI KARNIK, NIRANJAN SUBHASH, MERMELSTEIN, ROBIN J. · 2016 to 2024
$33.7M
Preservation of mucosal barrier in surgical diseasesR01DK064240 · NIDDK · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI TAN, XIAO-DI · 2004 to 2014
$3.0M
Role of the intestinal microvasculature in necrotizing enterocolitisR01DK116568 · NIDDK · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI DE PLAEN, ISABELLE G · 2019 to 2023
$2.7M
Insights into a multi-hit process in the development of necrotizing enterocolitisR01DK129960 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI TAN, XIAO-DI · 2022 to 2025
$2.6M
Mechanisms underlying regulation of intestinal epithelial homeostasis in sepsisR01DK123826 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI TAN, XIAO-DI · 2020 to 2023
$2.4M
Surgical studies of gut epithelial apoptosis-initiated critical illnessR01GM117628 · NIGMS · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI TAN, XIAO-DI · 2016 to 2019
$1.9M
Mechanisms underlying disruption of intestinal epithelial barrier in critical illnessR01GM122406 · NIGMS · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI TAN, XIAO-DI · 2017 to 2018
$594k
Mechanisms of trauma and hemorrhage-induced impairment of innate immunityI01BX001690 · VA · JESSE BROWN VA MEDICAL CENTER · PI TAN, XIAO-DI · 2013 to 2016
–
BLRD VA I01 BX001690NCATS NIH HHS UL1 TR002003NIDDK NIH HHS R01 DK064240NIDDK NIH HHS R01 DK116568NIDDK NIH HHS R01 DK123826NIDDK NIH HHS R01 DK129960NIGMS NIH HHS R01 GM117628NIGMS NIH HHS R01 GM122406
6 · The paper itself

Abstract

Feeding modes influence the gut microbiome, immune system, and intestinal barrier homeostasis in neonates; how feeding modes impact susceptibility to neonatal gastrointestinal (GI) diseases is still uncertain. Here, we investigated the impact of dam feeding (DF) and formula feeding (FF) on features of the gut microbiome and physiological inflammation during the first 2 days of postnatal development and on the susceptibility to intestinal injury related to the inflammatory state in neonatal mouse pups. 16S rRNA sequencing data revealed microbiome changes, lower α-diversity, and a distinct pattern of β-diversity including expansion of

Indexed as

Enterocolitis, NecrotizingGastrointestinal MicrobiomeAnimalsAnimals, NewbornDysbiosisHumansInflammationIntestinal MucosaMiceRNA, Ribosomal, 16SRNA, Ribosomal, 16Sgut microbiomeintestinal inflammationnecrotizing enterocolitis

Identifiers

PMID35819158
PMCPMC9394775
OpenAlexW4285076822

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.