Evidence map›Paper›PMID 35819053›Full record

ArticleAnnals of the New York Academy of Sciences2022

Nanoarchitecture and molecular interactions of epithelial cell junction proteins revealed by super-resolution microscopy.

Amna N Naser, William Guiler, Qun Lu, Yan-Hua Chen

Open access · greenAbstract read
In one paragraph

Article in Annals of the New York Academy of Sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Amna N NaserDepartment of Anatomy and Cell Biology, Brody School of Medicine, East Carolina University, Greenville, North Carolina, USA.
William GuilerDepartment of Anatomy and Cell Biology, Brody School of Medicine, East Carolina University, Greenville, North Carolina, USA.
Qun LuDepartment of Anatomy and Cell Biology, Brody School of Medicine, East Carolina University, Greenville, North Carolina, USA.
Yan-Hua ChenDepartment of Anatomy and Cell Biology, Brody School of Medicine, East Carolina University, Greenville, North Carolina, USA.
East Carolina University · US

Funding

Homeostatic Reset as a New Therapeutic Paradigm for Slow Progression DiseasesR01GM146257 · NIGMS · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI LU, QUN · 2021 to 2025
$3.4M
Role of claudin-7 in intestinal structure and inflammationR15DK103166 · NIDDK · EAST CAROLINA UNIVERSITY · PI CHEN, YAN-HUA · 2016 to 2016
$436k
NIDDK NIH HHS R15 DK103166NIGMS NIH HHS R01 GM146257
6 · The paper itself

Abstract

Epithelial cells are polarized with defined apical tight junctions (TJs), lateral adherens junctions (AJs), and basal integrin-matrix interactions. However, it is increasingly recognized that resident cell junction proteins can be found in varying locations and with previously unrecognized functions. Our study here presents the nanoarchitecture and nanocolocalization of cell junction proteins in culture and tissue by stochastic optical reconstruction microscopy (STORM). The Z-axial view of noncancerous MDCK-II and PZ-HPV-7 cell-cell junctions resolved β-catenin and p120

Indexed as

beta CateninMicroscopyAdherens JunctionsAnimalsCadherinsClaudin-1ClaudinsEpithelial Cell Adhesion MoleculeEpithelial CellsFocal Adhesion Protein-Tyrosine KinasesIntegrin alpha2MiceTight Junctionsbeta CateninCadherinsClaudin-1ClaudinsEpithelial Cell Adhesion MoleculeFocal Adhesion Protein-Tyrosine KinasesIntegrin alpha2cell junctionsclaudinsp120ctnSTORM imagingZO-1β-catenin

Identifiers

PMID35819053
PMCPMC9588527
OpenAlexW4285077449

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.