ArticleHuman brain mapping2022
Amygdala subnuclei volumes and anxiety behaviors in children and adolescents with autism spectrum disorder, attention deficit hyperactivity disorder, and obsessive-compulsive disorder.
Article in Human brain mapping, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Systematic Review: Convergence and Divergence Between Autism Spectrum Disorder and Obsessive-Compulsive Disorder: Genetic, Neuroimaging, and Cognitive Findings.Journal of the American Academy of Child and Adolescent Psychiatry · 2026Pooled it
- Autism spectrum disorder across the lifespan: Dynamic symptom trajectories and multidimensional support framework.Molecular psychiatry · 2026Review
- Identification of moderate effect size genes in autism spectrum disorder through a novel gene pairing approach.Communications biology · 2026Article
- Autism Spectrum Disorder and Perivascular Spaces: An Integrative Perspective Across the Lifespan.Journal of clinical medicine · 2025Review
- Factor Structure of RRBs in Verbal and Non-Verbal Preschoolers With ASD or Related Characteristics.Journal of autism and developmental disorders · 2025Article
- Subcortical brain volume variations in autistic individuals across the lifespan.Molecular autism · 2025Article
- Outdoor Air Pollution Is Related to Amygdala Subregion Volume and Apportionment in Early Adolescence.Biological psychiatry global open science · 2025Article
- Structural plasticity of the contralesional subfields of hippocampus and amygdala in patients with IDH-mutant astrocytoma and oligodendroglioma.Neuroradiology · 2025Article
- Understanding depression in autism: the role of subjective perception and anterior cingulate cortex volume.Molecular autism · 2025Article
- Early childhood stress and amygdala structure in children and adolescents with neurodevelopmental disorders.Brain structure & function · 2025Article
- Understanding Depression in Autism: The Role of Subjective Perception and Anterior Cingulate Cortex Volume.Research square · 2024Article
- MRI Volumetric Analysis of the Hypothalamus and Limbic System across the Pediatric Age Span.Children (Basel, Switzerland) · 2023Article
- Amygdala subnuclei volumes and anxiety behaviors in children and adolescents with autism spectrum disorder, attention deficit hyperactivity disorder, and obsessive-compulsive disorder.Human brain mapping · 2022Article
Corrections and comments
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Authors and funding
17 authors at 7 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alterations in the structural maturation of the amygdala subnuclei volumes are associated with anxiety behaviors in adults and children with neurodevelopmental and associated disorders. This study investigated the relationship between amygdala subnuclei volumes and anxiety in 233 children and adolescents (mean age = 11.02 years; standard deviation = 3.17) with autism spectrum disorder (ASD), attention deficit hyperactivity disorder (ADHD), and children with obsessive compulsive disorder (OCD), as well as typically developing (TD) children. Parents completed the Child Behavior Checklist (CBCL), and the children underwent structural MRI at 3 T. FreeSurfer software was used to automatically segment the amygdala subnuclei. A general linear model revealed that children and adolescents with ASD, ADHD, and OCD had higher anxiety scores compared to TD children (p < .001). A subsequent interaction analysis revealed that children with ASD (B = 0.09, p < .0001) and children with OCD (B = 0.1, p < .0001) who had high anxiety had larger right central nuclei volumes compared with TD children. Similar results were obtained for the right anterior amygdaloid area. Amygdala subnuclei volumes may be key to identifying children with neurodevelopmental disorders or those with OCD who are at high risk for anxiety. Findings may inform the development of targeted behavioral interventions to address anxiety behaviors and to assess the downstream effects of such interventions.
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