ArticleJournal of cachexia, sarcopenia and muscle2022
The influence of multiple frailty profiles on institutionalization and all-cause mortality in community-living older adults.
Article in Journal of cachexia, sarcopenia and muscle, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- The current state and development trends of frailty research in diabetic patients: a bibliometric analysis.Frontiers in medicine · 2025Pooled it
- Pooled it
- Article
- Doctors' and Pharmacists' knowledge, skills, and perception of mental frailty in older adults: a scoping review.BMC primary care · 2026Article
- A longitudinal study on multiple frailty and its associations with depression and social participation in older adults.Scientific reports · 2026Article
- Joint trajectories of frailty and depressive symptoms and risk of incident osteoarthritis in middle-aged and older adults.Frontiers in public health · 2026Article
- Evaluation of individual and composite CT-based markers in frailty diagnostics in older patients with cancer undergoing major abdominal surgery.BMC geriatrics · 2025Article
- Transition from depression-free to death in late life: characteristics of bidirectional transitions in depression symptoms.Epidemiology and psychiatric sciences · 2025Article
- Physical frailty and MRI markers of structural brain integrity in the community-dwelling late middle-aged and old adults.Scientific reports · 2025Article
- Development and testing of an electronic frailty index using Canadian electronic medical record data in primary care.BMC primary care · 2025Article
- Is accelerated biological aging the hidden link between physical frailty, social deficits, cognitive impairment and risk of incident diseases?The journal of nutrition, health & aging · 2025Article
- Review of Blood Pressure Control in Vulnerable Older Adults: The Role of Frailty and Sarcopenia.Journal of vascular diseases · 2025Article
- Frailty in Geriatrics: A Critical Review with Content Analysis of Instruments, Overlapping Constructs, and Challenges in Diagnosis and Prognostic Precision.Journal of clinical medicine · 2025Review
- Prevention and Mitigation of Frailty Syndrome in Institutionalised Older Adults Through Physical Activity: A Systematic Review.Healthcare (Basel, Switzerland) · 2025Review
- Development of a psychological frailty index: results from the China health and retirement longitudinal study.Frontiers in psychology · 2025Article
- Aging trajectories of subscales in higher-level functional capacity among community-dwelling older Japanese adults: the Otassha study.Aging clinical and experimental research · 2024Article
- One-year change in sarcopenia was associated with cognitive impairment among haemodialysis patients.Journal of cachexia, sarcopenia and muscle · 2023Article
- Protocols and Features of Goal-Setting-Based Intervention for Frail Older Adults in Community Exercise Facilities.International journal of environmental research and public health · 2023Article
- Differences in Characteristics Between Physical Frailty Assessments in Chronic Obstructive Pulmonary Disease: A Multicenter Cross-Sectional Observational Study.International journal of chronic obstructive pulmonary disease · 2023Observational
- The influence of multiple frailty profiles on institutionalization and all-cause mortality in community-living older adults.Journal of cachexia, sarcopenia and muscle · 2022Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundFrailty in older adults is associated with adverse geriatric outcomes. Physical frailty is often accompanied by problems in the cognitive, psychological, and social domains. This study investigated the ability of physical frailty combined with other health domains to predict institutionalization and mortality.
methodsA national sample of 9171 Koreans aged 65 years or older were surveyed at baseline in 2008 and 3 year follow-up. Those who were prefrail or frail according to the Fried criteria were conceived to have physical frailty. Psychological frailty, cognitive frailty, and social frailty were defined as having depressive symptoms, cognitive impairment, and social vulnerabilities, respectively, in addition to physical frailty. Using Cox proportional hazards and competing-risks regression, the risk of mortality and institutionalization by the number and profiles of different frailty domains was analysed.
resultsAt baseline, the 9171 participants were aged 73.1 (±6.8) years on average (median: 72, range: 65 to 103), and 59.2% were women. Multidomain frailty was highly prevalent (49.3%), with 6.1% concurrently displaying frailty in all four domains (mixed frailty). The risk of negative health outcomes increased with frailty in a higher number of domains with a subhazard ratio (SHR) of 3.48 (95% confidence interval [CI]: 1.83, 6.62; P < 0.001) for institutionalization and a hazard ratio (HR) of 3.95 (95% CI: 2.62, 5.93; P < 0.001) for mortality among those presenting mixed frailty. Psychological frailty (depressive symptoms combined with physical frailty) was strongly predictive of institutionalization (SHR = 2.85; 95% CI: 1.45, 5.59; P = 0.002) and mortality (HR = 2.47; 95% CI: 1.61, 3.78; P < 0.001). When combined with physical frailty and either depressive symptoms or social vulnerabilities, cognitive impairment also exhibited a significantly elevated risk of negative events. Physical frailty alone was not a strong predictor of adverse events, especially for mortality (HR = 1.13; 95% CI: 0.77, 1.67; P = 0.53).
conclusionsCo-occurrence of physical frailty with other domains is common in late life. The presence of frailty in multiple domains raises the risk of adverse outcomes, with the effects varying by multidimensional profiles.
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Registered trials
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