Evidence map›Paper›PMID 35818547›Full record

ArticleJACC. CardioOncology2022

Prevalence of Cardiovascular Disease in Patients With Potentially Curable Malignancies: A National Registry Dataset Analysis.

Nicolò Matteo Luca Battisti, Catherine A Welch, Michael Sweeting, Mark de Belder, John Deanfield, Clive Weston, Michael D Peake, David Adlam, Alistair Ring

Abstract read
In one paragraph

Article in JACC. CardioOncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. The intersection of colorectal cancer and cardiovascular disease: shared mechanisms and clinical implications.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Preoperative cardiovascular evaluation in patients with cancer.Frontiers in cardiovascular medicine · 2026
    Review
  14. Article
  15. Geographic variation in surgery rates among older patients with early (ER positive HER2 negative) breast cancer: Influence of cardiovascular disease and comorbidities: A national registry dataset analysis.European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology · 2025
    Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Nicolò Matteo Luca BattistiBreast Unit, Department of Medicine, The Royal Marsden NHS Foundation Trust, London, United Kingdom.
Catherine A WelchBiostatistics Research Team, Department of Health Sciences, University of Leicester, Leicester, United Kingdom.
Michael SweetingBiostatistics Research Team, Department of Health Sciences, University of Leicester, Leicester, United Kingdom.
Mark de BelderNational Institute for Cardiovascular Outcomes Research, London, United Kingdom.
John DeanfieldInstitute of Cardiovascular Sciences, University College London, London, United Kingdom.
Clive WestonMyocardial Ischaemia National Audit Project.
Michael D PeakePublic Health England, London, United Kingdom.
David AdlamDepartment of Cardiovascular Sciences, University of Leicester and Leicester National Institute of Health Research Biomedical Research Centre, Glenfield Hospital, Leicester, United Kingdom.
Alistair RingBreast Unit, Department of Medicine, The Royal Marsden NHS Foundation Trust, London, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Although a common challenge for patients and clinicians, there is little population-level evidence on the prevalence of cardiovascular disease (CVD) in individuals diagnosed with potentially curable cancer. Objectives: We investigated CVD rates in patients with common potentially curable malignancies and evaluated the associations between patient and disease characteristics and CVD prevalence. Methods: The study included cancer registry patients diagnosed in England with stage I to III breast cancer, stage I to III colon or rectal cancer, stage I to III prostate cancer, stage I to IIIA non-small-cell lung cancer, stage I to IV diffuse large B-cell lymphoma, and stage I to IV Hodgkin lymphoma from 2013 to 2018. Linked hospital records and national CVD databases were used to identify CVD. The rates of CVD were investigated according to tumor type, and associations between patient and disease characteristics and CVD prevalence were determined. Results: Among the 634,240 patients included, 102,834 (16.2%) had prior CVD. Men, older patients, and those living in deprived areas had higher CVD rates. Prevalence was highest for non-small-cell lung cancer (36.1%) and lowest for breast cancer (7.7%). After adjustment for age, sex, the income domain of the Index of Multiple Deprivation, and Charlson comorbidity index, CVD remained higher in other tumor types compared to breast cancer patients. Conclusions: There is a significant overlap between cancer and CVD burden. It is essential to consider CVD when evaluating national and international treatment patterns and cancer outcomes.

Indexed as

breast cancercolorectal cancerCVD, cardiovascular diseaseDLBCL, diffuse large B-cell lymphomaHES, Hospital Episode StatisticsICD-10, International Statistical Classification of Diseases and Related Health Problems-10th Revisionlung cancerlymphomaNCRD, National Cancer Registration DatasetNICOR, National Institute for Cardiovascular Outcomes ResearchNSCLC, non-small-cell lung cancerprostate cancer

Identifiers

PMID35818547
PMCPMC9270631

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.