Evidence map›Paper›PMID 35818505›Full record

ArticleJACC. Basic to translational science2022

Cardiac Spinal Afferent Denervation Attenuates Renal Dysfunction in Rats With Cardiorenal Syndrome Type 2.

Zhiqiu Xia, Neetha Nanoth Vellichirammal, Li Han, Lie Gao, Erika I Boesen, Alicia M Schiller, Peter R Pellegrino, Steven J Lisco, Chittibabu Guda, Irving H Zucker and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Basic to translational science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Zhiqiu XiaDepartment of Anesthesiology, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Neetha Nanoth VellichirammalDepartment of Genetics, Cell Biology, and Anatomy, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Li HanDepartment of Anesthesiology, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Lie GaoDepartment of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Erika I BoesenDepartment of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Alicia M SchillerDepartment of Anesthesiology, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Peter R PellegrinoDepartment of Anesthesiology, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Steven J LiscoDepartment of Anesthesiology, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Chittibabu GudaDepartment of Genetics, Cell Biology, and Anatomy, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Irving H ZuckerDepartment of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Han-Jun WangDepartment of Anesthesiology, University of Nebraska Medical Center, Omaha, Nebraska, USA.
University of Nebraska Medical Center · USHuazhong Agricultural University · CN

Funding

UNMC Structural Biology CoreP20GM103427 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI PAUL L SORGEN · 2012 to 2026
$59.2M
UNMC/EPPLEY CANCER CENTER SUPPORT GRANTP30CA036727 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Joann B. Sweasy · 1985 to 2026
$55.0M
Cardiac Sympathetic Afferent Denervation and Remodeling in Heart FailureR01HL126796 · NHLBI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI WANG, HANJUN, ZUCKER, IRVING H · 2016 to 2023
$4.3M
Novel Neural Mechanisms underlying Lung-Heart Pathological CrosstalkR01HL152160 · NHLBI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI WANG, HANJUN · 2020 to 2023
$2.2M
BDNF and the Exercise Pressor Reflex in Heart Fail.ureR01HL121012 · NHLBI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI WANG, HANJUN · 2016 to 2019
$1.5M
NCI NIH HHS P30 CA036727NHLBI NIH HHS R01 HL121012NHLBI NIH HHS R01 HL126796NHLBI NIH HHS R01 HL152160NIGMS NIH HHS P20 GM103427
6 · The paper itself

Abstract

Cardiorenal syndrome type 2 (CRS2) is defined as a chronic cardiovascular disease, usually chronic heart failure (CHF), resulting in chronic kidney disease. We hypothesized that the cardiac spinal afferent reflex (CSAR) plays a critical role in the development of CRS2. Our data suggest that cardiac afferent ablation by resiniferatoxin not only improves cardiac function but also benefits the kidneys and increases long-term survival in the myocardial infarction model of CHF. We also found that renal denervation has a similar reno-protective effect in CHF rats. We believe this novel work contributes to the development of a unique neuromodulation therapy to treat CHF patients.

Indexed as

BUN, blood urea nitrogencardiorenal syndrome type 2cardiovascular reflexesCHF, chronic heart failurechronic heart failureCRS2, cardiorenal syndrome type 2CSAR, cardiac spinal afferent reflexEF, ejection fractionFS, fractional shorteningGFR, glomerular filtration rateHR, heart rateinflammationKim-1, kidney injury molecule 1MAP, mean arterial blood pressureMI, myocardial infarctionNgal, neutrophil gelatinase–associated lipocalinRBF, renal blood flowrenal failureRTX, resiniferatoxinRVR, renal vascular resistancesympathoexcitationURDN, unilateral renal denervation

Identifiers

PMID35818505
PMCPMC9270585
OpenAlexW4283327734

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.