ArticleCrystal growth & design2022
On the Mechanism of Cocrystal Mechanochemical Reaction via Low Melting Eutectic: A Time-Resolved In Situ Monitoring Investigation.
Article in Crystal growth & design, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Machine learning-assisted development of a fast Mechanochemical Johnson-Corey-Chaykovsky reaction.Nature communications · 2026Article
- Unveiling Solvent-Mediated Mechanochemical Cocrystallization Pathways byMolecular pharmaceutics · 2026Article
- Pre-Activation as a Route for Tuning the Kinetics of Mechanochemical Transformations.Angewandte Chemie (International ed. in English) · 2026Article
- A Combined Experimental and Modeling Workflow to Tune Surface Properties of Organic Materials via Cocrystallization.Chemistry of materials : a publication of the American Chemical Society · 2025Article
- Salt or Cocrystal Puzzle Solved by Mechanochemistry: The Role of Solvent in the Pamoic Acid Case Study.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- Article
- Kinetics of the mechanochemical transformations in the "glycine - oxalic acid dihydrate" system revisited: The role of water.Frontiers in chemistry · 2025Article
- Structural diversity of cocrystals formed from acridine and two isomers of hydroxybenzaldehyde: 3-hydroxybenzaldehyde and 4-hydroxybenzaldehyde.RSC advances · 2023Article
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Authors and funding
5 authors.
Funding
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Abstract
Mechanochemistry has become a sustainable and attractive cost-effective synthetic technique, largely used within the frame of crystal engineering. Cocrystals, namely, crystalline compounds made of different chemical entities within the same crystal structure, are typically synthesized in bulk via mechanochemistry; however, whereas the macroscopic aspects of grinding are becoming clear, the fundamental principles that underlie mechanochemical cocrystallization at the microscopic level remain poorly understood. Time-resolved in situ (TRIS) monitoring approaches have opened the door to exceptional detail regarding mechanochemical reactions. We here report a clear example of cocrystallization between two solid coformers that proceeds through the formation of a metastable low melting binary eutectic phase. The overall cocrystallization process has been monitored by time-resolved in situ (TRIS) synchrotron X-ray powder diffraction with a customized ball milling setup, currently available at μSpot beamline at BESSY-II, Helmholtz-Zentrum Berlin. The binary system and the low melting eutectic phase were further characterized via DSC, HSM, and VT-XRPD.
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Registered trials
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