Trial reportJournal of the National Cancer Institute2022
A Randomized Trial of Telephone-Based Smoking Cessation Treatment in the Lung Cancer Screening Setting.
Trial report in Journal of the National Cancer Institute, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Integrating Evidence-Based Smoking Cessation Interventions Into Lung Cancer Screening Programs: A Randomized Trial
The Effect of Telephone-Assisted Smoking Cessation Program on Self-Efficacy, Smoking Behavior, Tumor Recurrence and Progression in Patients Diagnosed With Non-Muscle Invasive Bladder Cancer
Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Korean Clinical Practice Guideline of Korean Society for Research on Nicotine and Tobacco (KSRNT) and National Evidence-based Healthcare Collaborating Agency (NECA) on Treatment of Tobacco Use 2024.Journal of Korean medical science · 2025Guideline
- Strategies to deliver smoking cessation interventions during targeted lung health screening - a systematic review and meta-analysis.Chronic respiratory diseasePooled it
- Economic Evaluation of Tobacco Treatments From the Screen ASSIST Lung Cancer Screening Trial.JAMA network open · 2026Trial
- Exploring the predictors and barriers to accepting smoking cessation support within a targeted lung health check setting.BMJ open respiratory research · 2025Trial
- Gain-Framed Text Messages and Nicotine Replacement Therapy for Smoking Cessation Among Lung Cancer Screening Patients: A Brief Report of a Pilot Randomized Controlled Trial.International journal of environmental research and public health · 2025Trial
- Smoking Cessation Interventions in the Lung Cancer Screening Setting: A Randomized Clinical Trial.JAMA internal medicine · 2025Trial
- Effect of a Personalized Tobacco Treatment Intervention on Smoking Abstinence in Individuals Eligible for Lung Cancer Screening.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2024Trial
- A randomised controlled trial testing acceptance of practitioner-referral versus self-referral to stop smoking services within the Lung Screen Uptake Trial.Addiction (Abingdon, England) · 2023Trial
- Optimizing Longitudinal Tobacco Cessation Treatment in Lung Cancer Screening: A Sequential, Multiple Assignment, Randomized Trial.JAMA network open · 2023Trial
- Cost-Effectiveness of a Telephone-Based Smoking Cessation Randomized Trial in the Lung Cancer Screening Setting.JNCI cancer spectrum · 2022Trial
- Cost-Effectiveness of Smoking Cessation Interventions Integrated Into Lung Cancer Screening.JAMA network open · 2026Article
- Nicotine replacement therapy starter packs and gain-framed messages to promote smoking cessation in lung cancer screening: a randomized trial.American journal of respiratory and critical care medicine · 2026Article
- Missed opportunities for tobacco dependence treatment among U.S. veterans referred for lung Cancer screening: An observational cohort study.Preventive medicine reports · 2025Article
- Article
- Updates in Lung Cancer Screening: A Decade of Evidence.Seminars in respiratory and critical care medicine · 2025Review
- Article
- Association of Communication With Smoking Attitudes and Behaviors Among Patients Undergoing Lung Cancer Screening: A Longitudinal Cohort Study.CHEST pulmonary · 2025Article
- "Because That is the Right Thing to do": A Focus Group Study of Australian Expert Perspectives on Offering Smoking Cessation Support in Lung Cancer Screening.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2025Article
- Uptake and 4-week outcomes of an 'opt-out' smoking cessation referral strategy in a London-based lung cancer screening setting.BMJ open respiratory research · 2025Observational
- Polish consensus on smoking cessation intervention within lung cancer screening 1.Archives of medical science : AMS · 2025Article
Corrections and comments
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Authors and funding
17 authors.
Funding
Abstract
backgroundLung cancer mortality is reduced via low-dose computed tomography screening and treatment of early-stage disease. Evidence-based smoking cessation treatment in the lung screening setting can further reduce mortality. We report the results of a cessation trial from the National Cancer Institute's Smoking Cessation at Lung Examination collaboration.
methodsEligible patients (n = 818) aged 50-80 years were randomly assigned (May 2017-January 2021) to the intensive vs minimal arms (8 vs 3 phone sessions plus 8 vs 2 weeks of nicotine patches, respectively). Bio-verified (primary) and self-reported 7-day abstinence rates were assessed at 3, 6, and 12 months post random assignment. Logistic regression analyses evaluated the effects of study arm. All statistical tests were 2-sided.
resultsParticipants reported 48.0 (SD = 17.2) pack-years, and 51.6% were not ready to quit in less than 30 days. Self-reported 3-month quit rates were statistically significantly higher in the intensive vs minimal arm (14.3% vs 7.9%; odds ratio [OR] = 2.00, 95% confidence interval [CI] = 1.26 to 3.18). Bio-verified abstinence was lower but with similar relative differences between arms (9.1% vs 3.9%; OR = 2.70, 95% CI = 1.44 to 5.08). Compared with the minimal arm, the intensive arm was more effective among those with greater nicotine dependence (OR = 3.47, 95% CI = 1.55 to 7.76), normal screening results (OR = 2.58, 95% CI = 1.32 to 5.03), high engagement in counseling (OR = 3.03, 95% CI = 1.50 to 6.14), and patch use (OR = 2.81, 95% CI = 1.39 to 5.68). Abstinence rates did not differ statistically significantly between arms at 6 months (OR = 1.2, 95% CI = 0.68 to 2.11) or 12 months (OR = 1.4, 95% CI = 0.82 to 2.42).
conclusionsDelivering intensive telephone counseling and nicotine replacement with lung screening is an effective strategy to increase short-term smoking cessation. Methods to maintain short-term effects are needed. Even with modest quit rates, integrating cessation treatment into lung screening programs may have a large impact on tobacco-related mortality.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.