ArticleCritical care (London, England)2022
Effects of PEEP on regional ventilation-perfusion mismatch in the acute respiratory distress syndrome.
Article in Critical care (London, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 44 citations in OpenAlex.
- Personalized positive end-expiratory pressure in spontaneously breathing patients with acute respiratory distress syndrome by simultaneous electrical impedance tomography and transpulmonary pressure monitoring: a randomized crossover trial.Intensive care medicine · 2024Trial
- Electric impedance tomography-guided PEEP titration reduces mechanical power in ARDS: a randomized crossover pilot trial.Critical care (London, England) · 2023Trial
- EIT-assessed ventilation-perfusion responses to prone positioning and inhaled nitric oxide in mechanically ventilated COVID-19-related ARDS: a prospective sequential study.Journal of intensive care · 2026Article
- Flow-controlled expiration improves gas exchange in anaesthetised horses undergoing orthopaedic surgery.Equine veterinary journal · 2026Article
- Accuracy of electrical impedance tomography to detect perfusion defects in pulmonary embolism.Critical care (London, England) · 2026Article
- Ventilation/perfusion mismatch measured by electrical impedance tomography at the bedside: potentialities and challenges.Intensive care medicine · 2026Review
- Impact of PEEP on V/Q mismatch according to patient position and recruitability: a clinical prospective study.Annals of intensive care · 2026Article
- Imaging in animal models: bridging experimental findings and human pathophysiology.Critical care (London, England) · 2025Review
- Omics approach to chest electrical impedance tomography reveals physiological cluster of ARDS characterised by increased respiratory drive and effort.Annals of intensive care · 2025Article
- Imaging and pulmonary function techniques in ARDS diagnosis and management: current insights and challenges.Critical care (London, England) · 2025Review
- Time-dependent effects of prone position on ventilation-perfusion matching assessed by electrical impedance tomography in patients with COVID-19 ARDS: sub-analysis of a prospective physiological study.Annals of intensive care · 2025Article
- Calibration of ventilation/perfusion match in electrical impedance tomography: a novel method based on arterial blood pressure.Frontiers in physiology · 2025Article
- High flow nasal cannula and low level continuous positive airway pressure have different physiological effects during de novo acute hypoxemic respiratory failure.Annals of intensive care · 2024Article
- Electrical impedance tomography monitoring in adult ICU patients: state-of-the-art, recommendations for standardized acquisition, processing, and clinical use, and future directions.Critical care (London, England) · 2024Review
- Impact of airway closure and lung collapse on inhaled nitric oxide effect in acute lung injury: an experimental study.Annals of intensive care · 2024Article
- Effects of different VV ECMO blood flow rates on lung perfusion assessment by hypertonic saline bolus-based electrical impedance tomography.Critical care (London, England) · 2024Article
- Absolute values of regional ventilation-perfusion mismatch in patients with ARDS monitored by electrical impedance tomography and the role of dead space and shunt compensation.Critical care (London, England) · 2024Article
- Functional Phenotyping: A New Role for Electrical Impedance Tomography.American journal of respiratory and critical care medicine · 2024Article
- Imaging the pulmonary vasculature in acute respiratory distress syndrome.Nitric oxide : biology and chemistry · 2024Review
- Advanced Respiratory Monitoring during Extracorporeal Membrane Oxygenation.Journal of clinical medicine · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeIn the acute respiratory distress syndrome (ARDS), decreasing Ventilation-Perfusion [Formula: see text] mismatch might enhance lung protection. We investigated the regional effects of higher Positive End Expiratory Pressure (PEEP) on [Formula: see text] mismatch and their correlation with recruitability. We aimed to verify whether PEEP improves regional [Formula: see text] mismatch, and to study the underlying mechanisms.
methodsIn fifteen patients with moderate and severe ARDS, two PEEP levels (5 and 15 cmH
resultsIn the non-dependent region, at higher PEEP, ventilation reaching the normal [Formula: see text] compartment (p = 0.018) increased, while it decreased in the high [Formula: see text] one (p = 0.023). In the middle region, at PEEP 15 cmH
conclusionsIn patients with ARDS, higher PEEP optimizes the distribution of both ventilation (in the non-dependent areas) and perfusion (in the middle and dependent lung). Bedside measure of recruitability is associated with improved [Formula: see text] mismatch.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.