ReviewNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics2022
Deep Brain Stimulation for Depression.
Review in Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
89 citing papers in PubMed, 4 syntheses or guidelines pooled it, 148 citations in OpenAlex.
- Multilevel Mechanisms and Clinical Efficacy of Psilocybin in Depression Treatment: A Systematic Review.International journal of molecular sciences · 2026Pooled it
- Robot-Assisted versus non-robotic frame-based deep brain stimulation: a systematic review and meta-analysis of targeting accuracy and clinical outcomes.Journal of robotic surgery · 2026Pooled it
- Applications of machine learning in deep brain stimulation for major depressive disorder: a systematic review and meta-analysis.Neurosurgical review · 2025Pooled it
- Effects of deep brain stimulation on cognitive functioning in treatment-resistant depression: a systematic review and meta-analysis.Molecular psychiatry · 2023Pooled it
- Bed nucleus of the stria terminalis-nucleus accumbens stimulation for depression: A randomized, double-blind, crossover trial.Cell reports. Medicine · 2026Trial
- Reversible modulation of a deep white matter surgical target for depression with low-intensity focused ultrasound.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Trial
- Prefrontal-bed nucleus of the stria terminalis physiological and neuropsychological biomarkers predict therapeutic outcomes in depression.Nature communications · 2025Trial
- Noninvasive Modulation of the Subcallosal Cingulate and Depression With Focused Ultrasonic Waves.Biological psychiatry · 2025Trial
- Lack of neuropsychological effects following short-term subcallosal cingulate gyrus deep brain stimulation in treatment-resistant depression: a randomised crossover study.BMJ mental health · 2025Trial
- Deep brain stimulation mechanisms in comorbid pain and emotional dysregulation from animal models.iScience · 2026Review
- Akkermansia muciniphila : A next-generation gut probiotic supporting neurorepair and functional recovery.Neural regeneration research · 2026Article
- Ultralight infrared-controlled wireless neuromodulation systems for freely behaving mice.Microsystems & nanoengineering · 2026Article
- Next-Generation Neuromodulation for Anxiety: Circuit-Based and Personalized Approaches.Current psychiatry reports · 2026Review
- Single pulse electrical stimulation in white matter modulates iEEG visual responses in human early visual cortex.PLoS computational biology · 2026Article
- Electrical signatures of divergent connectivity in the human subgenual cingulate cortex.medRxiv : the preprint server for health sciences · 2026Article
- The Converging Effects of Different Categories of Antidepressants on the Brain: A Systematic Meta-Analysis of Public Transcriptional Profiling Data from the Hippocampus and Cortex.bioRxiv : the preprint server for biology · 2026Article
- Has Deep Brain Stimulation Shown Its Full Potential in Treatment-Resistant Depression? A Scoping Review.Biological psychiatry global open science · 2026Review
- Management of Treatment-Resistant Depression: An Updated Narrative Review of Current and Emerging Treatments.Cureus · 2026Review
- Deep Brain Stimulation for the Treatment of Treatment-Resistant Obsessive-Compulsive Disorder: A Meta-Analysis of Randomized Clinical Trials in 106 Patients.The Psychiatric quarterly · 2026Review
- A clinical study on the augmented therapeutic effects of transcutaneous auricular vagus nerve stimulation combined with repetitive transcranial magnetic stimulation in the treatment of moderate-to-severe depression.Pakistan journal of medical sciences · 2026Article
29 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Deep brain stimulation has been extensively studied as a therapeutic option for treatment-resistant depression (TRD). DBS across different targets is associated with on average 60% response rates in previously refractory chronically depressed patients. However, response rates vary greatly between patients and between studies and often require extensive trial-and-error optimizations of stimulation parameters. Emerging evidence from tractography imaging suggests that targeting combinations of white matter tracts, rather than specific grey matter regions, is necessary for meaningful antidepressant response to DBS. In this article, we review efficacy of various DBS targets for TRD, which networks are involved in their therapeutic effects, and how we can use this information to improve targeting and programing of DBS for individual patients. We will also highlight how to integrate these DBS network findings into developing adaptive stimulation and optimal trial designs.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.