ArticleNature metabolism2022
Food-seeking behavior is triggered by skin ultraviolet exposure in males.
Article in Nature metabolism, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Bone health: biology and nutrition.Current opinion in clinical nutrition and metabolic care · 2024Pooled it
- Associations between outdoor light exposure and low muscle mass: An NHANES 2011 to 2014 analysis.Medicine · 2026Article
- Dietary Supplementation withNutrients · 2026Article
- Association between solar radiation and mood disorders among Gulf Coast residents.Journal of exposure science & environmental epidemiology · 2025Article
- Peripheral substance P induces deficits in hippocampal synaptic plasticity and memory.Molecular brain · 2025Article
- Ultraviolet exposure of mice fed a high fat diet reduces weight gain and markers of liver disease progression.International journal of obesity (2005) · 2025Article
- Nutrition and Osteoporosis Prevention.Current osteoporosis reports · 2024Review
- Ghrelin induced by ultraviolet B exposure promotes the restoration of diabetic cutaneous wound healing.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2024Article
- Understanding the complexity of p53 in a new era of tumor suppression.Cancer cell · 2024Review
- Circadian-independent light regulation of mammalian metabolism.Nature metabolism · 2024Review
- Continuing benefits of the Montreal Protocol and protection of the stratospheric ozone layer for human health and the environment.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2024Article
- Photo-neuro-immuno-endocrinology: How the ultraviolet radiation regulates the body, brain, and immune system.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Sex Differences in the Relationship between Chronotype and Eating Behaviour: A Focus on Binge Eating and Food Addiction.Nutrients · 2023Article
- Solar ultraviolet B radiation promotes α-MSH secretion to attenuate the function of ILC2s via the pituitary-lung axis.Nature communications · 2023Article
- The Complex Effects of Light on Metabolism in Humans.Nutrients · 2023Review
- Skin epidermal keratinocyte p53 induces food uptake upon UV exposure.Frontiers in behavioral neuroscience · 2023Article
- Exposing skin to ultraviolet irradiation increases food intake in male individuals.Nature reviews. Endocrinology · 2022Article
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Authors and funding
38 authors at 9 institutions in 4 countries.
Funding
Abstract
Sexual dimorphisms are responsible for profound metabolic differences in health and behavior. Whether males and females react differently to environmental cues, such as solar ultraviolet (UV) exposure, is unknown. Here we show that solar exposure induces food-seeking behavior, food intake, and food-seeking behavior and food intake in men, but not in women, through epidemiological evidence of approximately 3,000 individuals throughout the year. In mice, UVB exposure leads to increased food-seeking behavior, food intake and weight gain, with a sexual dimorphism towards males. In both mice and human males, increased appetite is correlated with elevated levels of circulating ghrelin. Specifically, UVB irradiation leads to p53 transcriptional activation of ghrelin in skin adipocytes, while a conditional p53-knockout in mice abolishes UVB-induced ghrelin expression and food-seeking behavior. In females, estrogen interferes with the p53-chromatin interaction on the ghrelin promoter, thus blocking ghrelin and food-seeking behavior in response to UVB exposure. These results identify the skin as a major mediator of energy homeostasis and may lead to therapeutic opportunities for sex-based treatments of endocrine-related diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.