ArticleNature neuroscience2022
Reduced neural feedback signaling despite robust neuron and gamma auditory responses during human sleep.
Article in Nature neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 87 citations in OpenAlex.
- A randomized controlled trial of alpha phase-locked auditory stimulation to treat symptoms of sleep onset insomnia.Scientific reports · 2024Trial
- Exposure to broadband noise during non-REM sleep impairs hippocampal sharp-wave ripples and memory consolidation.Current biology : CB · 2026Article
- Review
- Neural mechanisms of awareness of action.PNAS nexus · 2026Article
- A week in the life of the human brain reveals stable states punctuated by chaotic-like transitions.Nature communications · 2026Article
- Multisensory integration in peripersonal space indexes consciousness states in sleep and disorders of consciousness.Cell reports. Medicine · 2026Article
- The Geometry of Layer 2/3 Cortical Sound Processing in Slow Wave Sleep.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Behavioral, experiential, and physiological signatures of mind blanking.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Circuit-level dynamics and propagation of slow wave activity modulate their interplay during the awakening process.iScience · 2025Article
- Sleep State Influences Early Sound Encoding at Cortical But Not Subcortical Levels.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Heterogeneous synaptic homeostasis: A novel mechanism boosting information propagation in the cortex.PLoS computational biology · 2025Article
- Modulation of Auditory Novelty Processing by Dexmedetomidine and Natural Sleep: A Human Intracranial Electrophysiology Study.The European journal of neuroscience · 2025Article
- Abrupt and Gradual Changes in Neuronal Processing upon Falling Asleep and Awakening.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Scream's roughness grants privileged access to the brain during sleep.Scientific reports · 2025Article
- Reducing Tinnitus via Inhibitory Influence of the Sensorimotor System on Auditory Cortical Activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Association of Bidirectional Network Cores in the Brain with Perceptual Awareness and Cognition.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Association of bidirectional network cores in the brain with perceptual awareness and cognition.bioRxiv : the preprint server for biology · 2025Article
- Auditory sensory processing induces cortical and thalamic event-related desynchronization in the mouse.PloS one · 2025Article
- Sleep-like cortical dynamics during wakefulness and their network effects following brain injury.Nature communications · 2024Review
- Article
Corrections and comments
- Erratum issued
Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
During sleep, sensory stimuli rarely trigger a behavioral response or conscious perception. However, it remains unclear whether sleep inhibits specific aspects of sensory processing, such as feedforward or feedback signaling. Here, we presented auditory stimuli (for example, click-trains, words, music) during wakefulness and sleep in patients with epilepsy, while recording neuronal spiking, microwire local field potentials, intracranial electroencephalogram and polysomnography. Auditory stimuli induced robust and selective spiking and high-gamma (80-200 Hz) power responses across the lateral temporal lobe during both non-rapid eye movement (NREM) and rapid eye movement (REM) sleep. Sleep only moderately attenuated response magnitudes, mainly affecting late responses beyond early auditory cortex and entrainment to rapid click-trains in NREM sleep. By contrast, auditory-induced alpha-beta (10-30 Hz) desynchronization (that is, decreased power), prevalent in wakefulness, was strongly reduced in sleep. Thus, extensive auditory responses persist during sleep whereas alpha-beta power decrease, likely reflecting neural feedback processes, is deficient. More broadly, our findings suggest that feedback signaling is key to conscious sensory processing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.